Primary sclerosing cholangitis (PSC) is a rare disorder characterised by multi-focal bile duct
strictures and progressive liver disease. Inflammatory bowel disease is usually present and …

Inclusion body myositis (IBM) is often viewed as an enigmatic disease with uncertain
pathogenic mechanisms and confusion around diagnosis, classification and prospects for …

In this review we develop the argument that cholestatic liver diseases, particularly primary
biliary cholangitis and primary sclerosing cholangitis (PSC), evolve over time with …

Primary Sclerosing Cholangitis | NEJM Skip to main content NEJM Group Follow Us Facebook
Twitter Instagram YouTube LinkedIn Prepare to become a physician, build your knowledge …

Background & Aims Little is known about the composition of intrahepatic immune cells and
their contribution to the pathogenesis of primary sclerosing cholangitis (PSC). Herein, we …

The human biliary system, a mucosal barrier tissue connecting the liver and intestine, is an
organ often affected by serious inflammatory and malignant diseases. Although these …

Vitamin D is becoming increasingly accepted as an important physiological regulator
outside of its classical role in skeletal homeostasis. A growing body of evidence connects …

Primary sclerosing cholangitis (PSC) is a chronic disease leading to fibrotic scarring of the
intrahepatic and extrahepatic bile ducts, causing considerable morbidity and mortality via …

There is ongoing evidence that vitamin D is related to the pathophysiology of cirrhosis.
Although the incidence of vitamin D deficiency in chronic liver diseases and cirrhosis is …

In addition to its well-documented involvement in mineral homeostasis, vitamin D seems to
have broad effects on human health that go beyond the skeletal system. Prominent among …