Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by the
presence of proliferative lesions throughout the body. Management of TSC is challenging …

Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disease caused by
mutations in either TSC1 or TSC2 genes. Approximately, two million individuals suffer from …

The lack of animal models for some human diseases precludes our understanding of
disease mechanisms and our ability to test prospective therapies in vivo. Generation of …

Tuberous sclerosis complex (TSC) is caused by mutations in either TSC1 or TSC2 genes
and affects multiple organs, including kidney, lung, and brain. In the kidney, TSC presents …

Tuberous sclerosis complex (TSC) is a multisystem tumor-forming disorder caused by loss of
TSC1 or TSC2. Renal manifestations predominately include cysts and angiomyolipomas …

Kidney cyst expansion in tuberous sclerosis complex (TSC) or polycystic kidney disease
(PKD) requires active secretion of chloride (Cl−) into the cyst lumen. In PKD, Cl− secretion is …

TSC renal cystic disease is poorly understood and has no approved treatment. In a new
principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is …

Declining kidney function in tuberous sclerosis complex (TSC) is often attributed to large
lesions, including angiomyolipomas (AMLs) and cysts, that encroach on the normal …

The tuberous sclerosis complex (Tsc) proteins regulate the conserved mTORC1 growth
regulation pathway. We identified that loss of the Tsc2 gene in mouse inner medullary …

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that affects both fetal
development and postnatal tissue growth, resulting in altered brain structures and a tumor …