[HTML][HTML] NRF2, a transcription factor for stress response and beyond
F He, X Ru, T Wen - International journal of molecular sciences, 2020 - mdpi.com
Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor that regulates the
cellular defense against toxic and oxidative insults through the expression of genes involved …
cellular defense against toxic and oxidative insults through the expression of genes involved …
Environmental pollutants and the immune response
T Suzuki, T Hidaka, Y Kumagai, M Yamamoto - Nature Immunology, 2020 - nature.com
Environmental pollution is one of the most serious challenges to health in the modern world.
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …
Pollutants alter immune responses and can provoke immunotoxicity. In this Review, we …
[HTML][HTML] NRF2 and the Hallmarks of Cancer
The transcription factor NRF2 is the master regulator of the cellular antioxidant response.
Though recognized originally as a target of chemopreventive compounds that help prevent …
Though recognized originally as a target of chemopreventive compounds that help prevent …
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler… - Physiological …, 2018 - journals.physiology.org
The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …
forms the major node of cellular and organismal defense against oxidative and electrophilic …
[HTML][HTML] Nrf2, the master regulator of anti-oxidative responses
S Vomund, A Schäfer, MJ Parnham, B Brüne… - International journal of …, 2017 - mdpi.com
Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …
without developing chronic inflammation. One of the major mediators of the resolution of …
Nrf2 in cancers: A double‐edged sword
S Wu, H Lu, Y Bai - Cancer medicine, 2019 - Wiley Online Library
Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
The hormetic dose-response mechanism: Nrf2 activation
EJ Calabrese, WJ Kozumbo - Pharmacological Research, 2021 - Elsevier
A generalized mechanism for hormetic dose responses is proposed that is based on the
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …
redox-activated transcription factor (TF), Nrf2, and its upregulation of an integrative system of …
[HTML][HTML] Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
EH Kobayashi, T Suzuki, R Funayama… - Nature …, 2016 - nature.com
Abstract Nrf2 (NF-E2-related factor-2) transcription factor regulates oxidative/xenobiotic
stress response and also represses inflammation. However, the mechanisms how Nrf2 …
stress response and also represses inflammation. However, the mechanisms how Nrf2 …
NRF2: KEAPing tumors protected
R Pillai, M Hayashi, AM Zavitsanou… - Cancer Discovery, 2022 - AACR
The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …
NRF2 as a regulator of cell metabolism and inflammation in cancer
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …