Biological function of Foot-and-mouth disease virus non-structural proteins and non-coding elements

Y Gao, SQ Sun, HC Guo - Virology journal, 2016 - Springer
Foot-and-mouth disease virus (FMDV) represses host translation machinery, blocks protein
secretion, and cleaves cellular proteins associated with signal transduction and the innate …

The carrier conundrum; a review of recent advances and persistent gaps regarding the carrier state of foot-and-mouth disease virus

C Stenfeldt, J Arzt - Pathogens, 2020 - mdpi.com
The existence of a prolonged, subclinical phase of foot-and-mouth disease virus (FMDV)
infection in cattle was first recognized in the 1950s. Since then, the FMDV carrier state has …

The pathogenesis of foot-and-mouth disease in pigs

C Stenfeldt, F Diaz-San Segundo… - Frontiers in veterinary …, 2016 - frontiersin.org
The greatest proportion of foot-and-mouth disease (FMD) clinical research has been
dedicated to elucidating pathogenesis and enhancing vaccine protection in cattle with less …

Foot-and-mouth disease virus: Prospects for using knowledge of virus biology to improve control of this continuing global threat

GJ Belsham, T Kristensen, T Jackson - Virus research, 2020 - Elsevier
Understanding of the biology of foot-and-mouth disease virus (FMDV) has grown
considerably since the nucleotide sequence of the viral RNA was determined. The ability to …

Foot-and-mouth disease virus non-structural protein 3A inhibits the interferon-β signaling pathway

D Li, C Lei, Z Xu, F Yang, H Liu, Z Zhu, S Li, X Liu… - Scientific reports, 2016 - nature.com
Foot-and-mouth disease virus (FMDV) is the etiological agent of FMD, which affects cloven-
hoofed animals. The pathophysiology of FMDV has not been fully understood and the …

The different tactics of foot-and-mouth disease virus to evade innate immunity

GN Medina, FDS Segundo, C Stenfeldt, J Arzt… - Frontiers in …, 2018 - frontiersin.org
Like all pathogens, foot-and-mouth disease virus (FMDV) is recognized by the immune
system inducing a heightened immune response mainly mediated by type I and type III IFNs …

Parameterization of the durations of phases of foot-and-mouth disease in cattle

S Yadav, C Stenfeldt, MA Branan… - Frontiers in Veterinary …, 2019 - frontiersin.org
The objective of the current study was to update parameterization of mathematical
simulation models for foot-and-mouth disease (FMD) spread in cattle utilizing recent …

Early events in the pathogenesis of foot-and-mouth disease in pigs; identification of oropharyngeal tonsils as sites of primary and sustained viral replication

C Stenfeldt, JM Pacheco, LL Rodriguez, J Arzt - PLoS One, 2014 - journals.plos.org
A time-course study was performed to elucidate the early events of foot-and-mouth disease
virus (FMDV) infection in pigs subsequent to simulated natural, intra-oropharyngeal …

Picornaviruses: a view from 3A

T Jackson, GJ Belsham - Viruses, 2021 - mdpi.com
Picornaviruses are comprised of a positive-sense RNA genome surrounded by a protein
shell (or capsid). They are ubiquitous in vertebrates and cause a wide range of important …

Interaction of foot-and-mouth disease virus nonstructural protein 3A with host protein DCTN3 is important for viral virulence in cattle

DP Gladue, V O'donnell, R Baker-Bransetter… - Journal of …, 2014 - Am Soc Microbiol
Nonstructural protein 3A of foot-and-mouth disease virus (FMDV) is a partially conserved
protein of 153 amino acids in most FMDVs examined to date. The role of 3A in virus growth …