Different neuroplastic processes can occur along the nociceptive pathways and may be
important in the transition from acute to chronic pain and for diagnosis and development of …

Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However,
the mechanisms of OA pain are poorly understood. This review addresses the mechanisms …

Patients with knee osteoarthritis demonstrate decreased pressure pain thresholds (PPTs),
facilitated temporal summation (TS) of pain, and decreased conditioned pain modulation …

Osteoarthritis (OA) is a global disease that, despite extensive research, has limited treatment
options. Pet dogs share both an environment and lifestyle attributes with their owners, and a …

Musculoskeletal pain disorders are the second largest contributor to global disability
underlining the significance of effective treatments. However, treating chronic …

Knee osteoarthritis (KOA) is the most common form of joint degeneration with increasing
prevalence and incidence in recent decades. KOA is a molecular disorder characterized by …

Chronic postoperative pain after total knee replacement (TKR) in knee osteoarthritis (KOA)
implies clinical challenges. Widespread hyperalgesia, facilitated temporal summation of …

Treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in
particular, is challenging as the peripheral and central pain mechanisms are not fully …

Animal models of osteoarthritis are extensively used for investigating disease pathways and
for preclinical testing of novel therapies. Their predictive utility, however, has often been …

Valid and reliable biomarkers can play an important role in clinical trials as indicators of
biological or pathogenic processes or as a signal of treatment response. Currently, there are …