APOE in the bullseye of neurodegenerative diseases: impact of the APOE genotype in Alzheimer's disease pathology and brain diseases
R Fernández-Calle, SC Konings… - Molecular …, 2022 - Springer
ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …
[HTML][HTML] MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets
S Liu, M Fan, Q Zheng, S Hao, L Yang, Q Xia… - Biomedicine & …, 2022 - Elsevier
Alzheimer's disease (AD) is the most common neurodegenerative disease, with cognitive
decline as the primary clinical feature. According to epidemiological statistics, 50 million …
decline as the primary clinical feature. According to epidemiological statistics, 50 million …
TREM2 in the pathogenesis of AD: a lipid metabolism regulator and potential metabolic therapeutic target
RY Li, Q Qin, HC Yang, YY Wang, YX Mi, YS Yin… - Molecular …, 2022 - Springer
Triggering receptor expressed on myeloid cells 2 (TREM2) is a single-pass transmembrane
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …
immune receptor that is mainly expressed on microglia in the brain and macrophages in the …
Human microRNA (miR-20b-5p) modulates Alzheimer's disease pathways and neuronal function, and a specific polymorphism close to the MIR20B gene influences …
Alzheimer's disease (AD) is a progressive neurodegenerative disorder with loss of cognitive,
executive, and other mental functions, and is the most common form of age-related …
executive, and other mental functions, and is the most common form of age-related …
Roles of non-coding RNA in alzheimer's disease pathophysiology
EO Olufunmilayo, RMD Holsinger - International journal of molecular …, 2023 - mdpi.com
Alzheimer's disease (AD) is a chronic neurodegenerative disorder that is accompanied by
deficits in memory and cognitive functions. The disease is pathologically characterised by …
deficits in memory and cognitive functions. The disease is pathologically characterised by …
Microglia specific deletion of miR-155 in Alzheimer's disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures
Alzheimer's Disease (AD) is characterized by the accumulation of extracellular amyloid-β
(Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the …
(Aβ) as well as CNS and systemic inflammation. Microglia, the myeloid cells resident in the …
Exosome based miRNA delivery strategy for disease treatment
Abstract miRNA, which is a common non-coding RNA, can target various mRNAs to regulate
their physiological activities. Therefore, miRNAs play an important role in various …
their physiological activities. Therefore, miRNAs play an important role in various …
The eminent role of microRNAs in the pathogenesis of Alzheimer's disease
Alzheimer's disease (AD) is an irrevocable neurodegenerative condition characterized by
the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and …
the presence of senile plaques comprising amassed β-amyloid peptides (Aβ) and …
Dysregulated miRNAs as biomarkers and therapeutical targets in neurodegenerative diseases
Alzheimer's disease (AD), Parkinson's disease (PD), and Amyotrophic Lateral Sclerosis
(ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration …
(ALS) are representative neurodegenerative diseases (NDs) characterized by degeneration …
Alzheimer's disease-related epigenetic changes: novel therapeutic targets
A Paniri, MM Hosseini, H Akhavan-Niaki - Molecular Neurobiology, 2024 - Springer
Aging is a significant risk factor for Alzheimer's disease (AD), although the precise
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …
mechanism and molecular basis of AD are not yet fully understood. Epigenetic mechanisms …