Non-spherical micro-and nanoparticles for drug delivery: Progress over 15 years

N Kapate, JR Clegg, S Mitragotri - Advanced Drug Delivery Reviews, 2021 - Elsevier
Shape of particulate drug carries has been identified as a key parameter in determining their
biological outcome. In this review, we analyze the field of particle shape as it shifts from …

Medulloblastoma targeted therapy: From signaling pathways heterogeneity and current treatment dilemma to the recent advances in development of therapeutic …

Q Wang, X Xin, Q Dai, M Sun, J Chen… - Pharmacology & …, 2023 - Elsevier
Medulloblastoma (MB) is a major pediatric malignant brain tumor that arises in the
cerebellum. MB tumors exhibit highly heterogeneous driven by diverse genetic alterations …

Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications

M Fonseca, I Jarak, F Victor, C Domingues, F Veiga… - Materials, 2024 - mdpi.com
Polymersomes are artificial nanoparticles formed by the self-assembly process of
amphiphilic block copolymers composed of hydrophobic and hydrophilic blocks. They can …

Intelligent design of polymersomes for antibacterial and anticancer applications

T Wang, J Qin, J Cheng, C Li… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Polymersomes (or polymer vesicles) have attracted much attention for biomedical
applications in recent years because their lumen can be used for drug delivery and their …

[HTML][HTML] Clusters of polymersomes and Janus nanoparticles hierarchically self-organized and controlled by DNA hybridization

V Mihali, M Skowicki, D Messmer, CG Palivan - Nano Today, 2023 - Elsevier
The combination of “hard”, structurally well-defined particles with “soft”, functional
compartments bears great potential to produce structurally intricate hybrid nanomaterials …

Peptide ligands on the PEGylated nanoparticle surface and human serum composition are key factors for the interaction between immune cells and nanoparticles

AG Pershina, AM Demin, NA Perekucha… - Colloids and Surfaces B …, 2023 - Elsevier
The architecture of a nanoparticles' surface formed due to a modification with a ligand and
protein corona formation in biofluids is critical for interactions with cells in vivo. Here we …

Synthetic Cells Revisited: Artificial Cells Construction Using Polymeric Building Blocks

V Maffeis, L Heuberger, A Nikoletić… - Advanced …, 2024 - Wiley Online Library
The exponential growth of research on artificial cells and organelles underscores their
potential as tools to advance the understanding of fundamental biological processes. The …

Nonspherical nanocapsules as long-circulating drug delivery systems

Y Xiao, A Tan, AW Jackson, BJ Boyd - Chemistry of Materials, 2022 - ACS Publications
Polymeric nanocapsules have been studied as drug delivery carriers for a great variety of
drugs for more than 30 years. In particular, nonspherical polymeric nanoparticles with solid …

Convoluted micellar morphological transitions driven by tailorable mesogenic ordering effect from discotic mesogen-containing block copolymer

H Yang, Y Luo, B Jin, S Chi, X Li - Nature Communications, 2024 - nature.com
Solution-state self-assemblies of block copolymers to form nanostructures are tremendously
attractive for their tailorable morphologies and functionalities. While incorporating moieties …

Combining nanoparticle shape modulation and polymersome technology in drug delivery

C Katterman, C Pierce, J Larsen - ACS applied bio materials, 2021 - ACS Publications
This paper highlights the potential benefits of using self-assembled polymeric nanoparticles
of various shapes to enhance drug uptake. First, we highlight the growth and development of …