The search for natural and synthetic inhibitors that would complement antivenoms as therapeutics for snakebite envenoming

JM Gutiérrez, LO Albulescu, RH Clare, NR Casewell… - Toxins, 2021 - mdpi.com
A global strategy, under the coordination of the World Health Organization, is being unfolded
to reduce the impact of snakebite envenoming. One of the pillars of this strategy is to ensure …

From fangs to pharmacology: the future of snakebite envenoming therapy

AH Laustsen, M Engmark, C Milbo… - Current …, 2016 - ingentaconnect.com
The snake is the symbol of medicine due to its association with Asclepius, the Greek God of
medicine, and so with good reasons. More than 725 species of venomous snakes have …

Progress and Challenges in the Field of Snakebite Envenoming Therapeutics

JM Gutiérrez, N R. Casewell… - Annual Review of …, 2024 - annualreviews.org
Snakebite envenoming kills and maims hundreds of thousands of people every year,
especially in the rural settings of tropical regions. Envenomings are still treated with animal …

Tissue damaging toxins in snake venoms: Mechanisms of action, pathophysiology and treatment strategies

MA Bittenbinder, J van Thiel, FC Cardoso… - Communications …, 2024 - nature.com
Snakebite envenoming is an important public health issue responsible for mortality and
severe morbidity. Where mortality is mainly caused by venom toxins that induce …

Structural basis for phospholipase A2-like toxin inhibition by the synthetic compound Varespladib (LY315920)

GHM Salvador, AAS Gomes, W Bryan-Quirós… - Scientific Reports, 2019 - nature.com
Abstract The World Health Organization recently listed snakebite envenoming as a
Neglected Tropical Disease, proposing strategies to significantly reduce the global burden …

Medicinal plants used to treat snakebite in Central America: Review and assessment of scientific evidence

P Giovannini, MJR Howes - Journal of ethnopharmacology, 2017 - Elsevier
Ethnopharmacological relevance Every year between 1.2 and 5.5 million people worldwide
are victims of snakebites, with about 400,000 left permanently injured. In Central America an …

Computational investigations of physicochemical, pharmacokinetic, toxicological properties and molecular docking of betulinic acid, a constituent of Corypha taliera …

MF Khan, N Nahar, RB Rashid, A Chowdhury… - … and alternative medicine, 2018 - Springer
Background Betulinic acid (BA) is a natural triterpenoid compound and exhibits a wide
range of biological and medicinal properties including anti-inflammatory activity. Therefore …

Developing small molecule therapeutics for the initial and adjunctive treatment of snakebite

TC Bulfone, SP Samuel, PE Bickler… - Journal of tropical …, 2018 - Wiley Online Library
The World Health Organization (WHO) recently added snakebite envenoming to the priority
list of Neglected Tropical Diseases (NTD). It is thought that~ 75% of mortality following …

Snake venom peptides and low mass proteins: molecular tools and therapeutic agents

JR Almeida, LM Resende, RK Watanabe… - Current medicinal …, 2017 - ingentaconnect.com
Snake venoms are natural sources of biologically active molecules that are able to act
selectively and specifically on different cellular targets, modulating physiological functions …

Hyaluronidase, phospholipase A2 and protease inhibitory activity of plants used in traditional treatment of snakebite-induced tissue necrosis in Mali, DR Congo and …

M Molander, L Nielsen, S Søgaard, D Staerk… - Journal of …, 2014 - Elsevier
Ethnopharmacological relevance Snakebite envenomation, every year, causes estimated 5–
10,000 mortalities and results in more than 5–15,000 amputations in sub-Saharan Africa …