HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

M Lechner, J Liu, L Masterson, TR Fenton - Nature reviews Clinical …, 2022 - nature.com
Abstract Human papillomavirus (HPV)-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) has one of the most rapidly increasing incidences of any cancer in high …

Major changes in head and neck staging for 2018

W Lydiatt, B O'Sullivan, S Patel - American Society of Clinical …, 2018 - ascopubs.org
Oncologists should be aware of three major modifications and additions to staging head and
neck cancer that became effective in 2018. Oral cavity cancers have the addition of depth of …

[HTML][HTML] Acoustofluidic salivary exosome isolation: a liquid biopsy compatible approach for human papillomavirus–associated oropharyngeal cancer detection

Z Wang, F Li, J Rufo, C Chen, S Yang, L Li… - The Journal of Molecular …, 2020 - Elsevier
Previous efforts to evaluate the detection of human papilloma viral (HPV) DNA in whole
saliva as a diagnostic measure for HPV-associated oropharyngeal cancer (HPV-OPC) have …

Absolute risk of oropharyngeal cancer after an HPV16-E6 serology test and potential implications for screening: results from the human papillomavirus cancer cohort …

HA Robbins, A Ferreiro-Iglesias… - Journal of Clinical …, 2022 - ascopubs.org
PURPOSE Seropositivity for the HPV16-E6 oncoprotein is a promising marker for early
detection of oropharyngeal cancer (OPC), but the absolute risk of OPC after a positive or …

Deintensification of treatment for human papillomavirus-related oropharyngeal cancer: Current state and future directions

EO Bigelow, TY Seiwert, C Fakhry - Oral oncology, 2020 - Elsevier
Human papillomavirus (HPV)-related oropharyngeal squamous cell cancer (OPSCC) has
emerged as a distinct clinical entity of head and neck cancer with expected high survival …

Clinical, morphologic and molecular heterogeneity of HPV-associated oropharyngeal cancer

YX Lim, ML Mierzwa, MA Sartor, NJ D'Silva - Oncogene, 2023 - nature.com
The incidence of human papillomavirus-positive (HPV+) oropharyngeal squamous cell
carcinoma (OPSCC) is rising rapidly and has exceeded cervical cancer to become the most …

A review of the 8th edition of the AJCC staging system for oropharyngeal cancer according to HPV status

P Machczyński, E Majchrzak, P Niewinski… - European Archives of …, 2020 - Springer
Background The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has
increased substantially in recent decades, particularly p16-positive human papillomavirus …

Recommendations for determining HPV status in patients with oropharyngeal cancers under TNM8 guidelines: a two-tier approach

SG Craig, LA Anderson, AG Schache, M Moran… - British Journal of …, 2019 - nature.com
Background TNM8 staging for oropharyngeal squamous cell carcinomas (OPSCC)
surrogates p16 immunohistochemistry for HPV testing. Patients with p16+ OPSCC may lack …

[HTML][HTML] Summary from an international cancer seminar focused on human papillomavirus (HPV)-positive oropharynx cancer, convened by scientists at IARC and NCI

AR Kreimer, AK Chaturvedi, L Alemany… - Oral oncology, 2020 - Elsevier
Cancer of the oropharynx has attracted considerable attention in recent years given:(1) an
increasing incidence in selected populations over the past three decades;(2) the discovery …

Extranodal extension is a strong prognosticator in HPV‐positive oropharyngeal squamous cell carcinoma

E Bauer, A Mazul, R Chernock, J Rich… - The …, 2020 - Wiley Online Library
Objective To comprehensively examine the prognostic significance of extranodal extension
(ENE) in human papillomavirus–positive oropharyngeal squamous cell carcinoma (HPV …