Contingent upon concentration, reactive oxygen species (ROS) influence cancer evolution
in apparently contradictory ways, either initiating/stimulating tumorigenesis and supporting …

The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Abstract Hydrogen peroxide (H2O2) is a major reactive oxygen species in unicellular and
multicellular organisms, and is produced extracellularly in response to external stresses and …

Abstract Transient Receptor Potential (TRP) channels are evolutionarily conserved integral
membrane proteins. The mammalian TRP superfamily of ion channels consists of 28 cation …

The TRPA1 ion channel (also known as the wasabi receptor) is a detector of noxious
chemical agents encountered in our environment or produced endogenously during tissue …

The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …

Piezo ion channels are activated by various types of mechanical stimuli and function as
biological pressure sensors in both vertebrates and invertebrates. To date, mechanical …

Arachidonic acid-derived prostaglandins not only contribute to the development of
inflammation as intercellular pro-inflammatory mediators, but also promote the excitability of …

Cutaneous neurogenic inflammation (CNI) is inflammation that is induced (or enhanced) in
the skin by the release of neuropeptides from sensory nerve endings. Clinical manifestations …

Chemistry, traditionally being the science of synthesis and structural manipulations of
molecules, has gradually undertaken the more challenging task of biology-oriented …