Single-cell transcriptomics has broadened our understanding of cellular diversity and gene
expression dynamics in healthy and diseased tissues. Recently, spatial transcriptomics has …

Human tissue, which is inherently three-dimensional (3D), is traditionally examined through
standard-of-care histopathology as limited two-dimensional (2D) cross-sections that can …

Spatial organization plays a fundamental role in biology, influencing the function of
biological structures at various levels. The immune system, in particular, relies on the …

The amyloid plaque niche is a pivotal hallmark of Alzheimer's disease (AD). Here, we
employ two high-resolution spatial transcriptomics (ST) platforms, CosMx and Spatial …

Highlights•Mass spectrometry–based proteomics is ready to transform clinical
diagnostics.•Spatial proteomics revolutionizes disease mechanism studies.•Population …

The innovations in functional genomics have provided a pathway for the identification and
prediction of potential druggable human genes that help in the innovation of drug discovery …

We introduce Vespucci, a machine-learning method to identify perturbation-responsive
regions, genes and gene programs within comparative spatial transcriptomics atlases. We …

We present STIM, an imaging-based computational framework focused on visualizing and
aligning high-throughput spatial sequencing datasets. STIM is built on the powerful, scalable …

The amyloid plaque cell niche is a pivotal hallmark of Alzheimer's disease (AD). Where early
spatial transcriptomics (ST) technologies have provided valuable information on …