The transition from acute to chronic pain appears to occur in discrete pathophysiological and
histopathological steps. Stimuli initiating a nociceptive response vary, but receptors and …

Effective therapeutic options for patients living with chronic pain are limited. The pain
relieving effect of cannabinoids remains unclear. A systematic review of randomized …

The identification of new bioactive compounds derived from medicinal plants with significant
therapeutic properties has attracted considerable interest in recent years. Such is the case of …

The therapeutic potential of cannabinoids has been the topic of extensive investigation
following the discovery of cannabinoid receptors and their endogenous ligands …

In the last 25 years data has grown exponentially dealing with the discovery of the
endocannabinoid system consisting of specific cannabinoid receptors, their endogenous …

A large body of evidence now exists to substantiate that the endocannabinoid, anandamide,
activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a …

Background The past two decades have seen an increase in cannabis use due to both
regulatory changes and an interest in potential therapeutic effects of the substance, yet …

The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …

Cannabis extracts and synthetic cannabinoids are still widely considered illegal substances.
Preclinical and clinical studies have suggested that they may result useful to treat diverse …

2-Arachidonoylglycerol (2-AG) is a unique molecular species of monoacylglycerol isolated
in 1995 from rat brain and canine gut as an endogenous ligand for the cannabinoid …