Transmission-blocking drugs for malaria elimination

LM Birkholtz, P Alano, D Leroy - Trends in parasitology, 2022 - cell.com
Preventing human-to-mosquito transmission of malaria parasites provides possible
solutions to interrupt the malaria parasite life cycle for malaria elimination. The development …

Plasmodium vivax: the potential obstacles it presents to malaria elimination and eradication

K Habtamu, B Petros, G Yan - Tropical Diseases, Travel Medicine and …, 2022 - Springer
Initiatives to eradicate malaria have a good impact on P. falciparum malaria worldwide. P.
vivax, however, still presents significant difficulties. This is due to its unique biological traits …

Antimalarial Drug Strategies to Target Plasmodium Gametocytes

BA Munro, BJ McMorran - Parasitologia, 2022 - mdpi.com
Onward transmission of Plasmodium falciparum from humans to mosquitoes is dependent
upon a specialised transmission stage called the gametocyte. Despite its critical role in …

Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure

S Mehra, E Stadler, D Khoury, JM McCaw… - Journal of Theoretical …, 2022 - Elsevier
Malaria is a mosquito-borne disease with a devastating global impact. Plasmodium vivax is
a major cause of human malaria beyond sub-Saharan Africa. Relapsing infections, driven by …

Comparison of PvLAP5 and Pvs25 qRT-PCR assays for the detection of Plasmodium vivax gametocytes in field samples preserved at ambient temperature from …

N Obaldía, I Barahona, J Lasso, M Avila… - PLoS neglected …, 2022 - journals.plos.org
Background As the elimination of malaria in Mesoamerica progresses, detection of
Plasmodium vivax using light microscopy (LM) becomes more difficult. Highly sensitive …

Plasmodium falciparum and Plasmodium vivax Adjust Investment in Transmission in Response to Change in Transmission Intensity: A Review of the Current State of …

CO Oduma, C Koepfli - Frontiers in Cellular and Infection …, 2021 - frontiersin.org
Malaria parasites can adjust the proportion of parasites that develop into gametocytes, and
thus the probability for human-to-vector transmission, through changes in the gametocyte …

Update on pathogenesis, management, and control of Plasmodium vivax

N Khan, JP Daily - Current opinion in infectious diseases, 2022 - journals.lww.com
P. vivax is a significant global health problem. There have been recent developments in
understanding the complexity of P. vivax biology and optimization of antimalarial therapy …

qPCR in a suitcase for rapid Plasmodium falciparum and Plasmodium vivax surveillance in Ethiopia

L Carlier, SC Baker, T Huwe, D Yewhalaw… - PLOS Global Public …, 2022 - journals.plos.org
Many Plasmodium spp. infections, both in clinical and asymptomatic patients, are below the
limit of detection of light microscopy or rapid diagnostic test (RDT). Molecular diagnosis by …

Plasmodium gametocyte carriage in humans and sporozoite rate in anopheline mosquitoes in Gondar zuria district, Northwest Ethiopia

A Minwuyelet, M Abiye, AJ Zeleke, S Getie - Plos one, 2024 - journals.plos.org
Although the overall burden of malaria is decreasing in Ethiopia, a recent report of an
unpredictable increased incidence may be related to the presence of community-wide …

Freedom from infection: enhancing decision-making for malaria elimination

L Nelli, H Surendra, I Byrne, RA Ahmad, RR Arisanti… - BMJ Global …, 2024 - gh.bmj.com
Assessing elimination of malaria locally requires a surveillance system with high sensitivity
and specificity to detect its presence without ambiguity. Currently, the WHO standard criteria …