Drug absorption from the gastrointestinal (GI) tract is a highly complex process dependent
upon numerous factors including the physicochemical properties of the drug, characteristics …

Modeling and simulation of drug disposition has emerged as an important tool in drug
development, clinical study design and regulatory review, and the number of physiologically …

Membrane transport proteins are involved in the absorption, disposition, efficacy, and/or
toxicity of many drugs. Numerous mechanisms (eg, nuclear receptors, epigenetic gene …

According to current US Food and Drug Administration (FDA) and European Medicines
Agency (EMA) guidance documents, physiologically based pharmacokinetic (PBPK) …

Physiologically‐based pharmacokinetic (PBPK) modeling has been extensively used to
quantitatively translate in vitro data and evaluate temporal effects from drug–drug …

Objectives Using the type of meal and dosing conditions suggested by regulatory agencies
as a basis, this review has two specific objectives: first, to summarize our understanding on …

There is an increasing interest in transporter induction (ie, decreased systemic drug
exposure due to increased efflux‐limited absorption or transporter‐mediated clearance) as a …

The occurrence of drug–drug interactions (DDIs) can significantly affect the safety of a
patient, and thus assessing DDI risk is important. Recently, physiologically based …

Physiologically‐based pharmacokinetic (PBPK) modeling is a powerful tool to quantitatively
describe drug disposition profiles in vivo, thereby providing an alternative to predict drug …

Drug absorption in the intestine is tightly related to drug-induced nephrotoxicity, which is a
relatively common side effect in clinical practice. It highlights a great need to develop …