The rise of genomics in snake venom research: recent advances and future perspectives
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …
Snake venomics: fundamentals, recent updates, and a look to the next decade
CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …
Functional genomic diversity is correlated with neutral genomic diversity in populations of an endangered rattlesnake
Theory predicts that genetic erosion in small, isolated populations of endangered species
can be assessed using estimates of neutral genetic variation, yet this widely used approach …
can be assessed using estimates of neutral genetic variation, yet this widely used approach …
Micro and macroevolution of sea anemone venom phenotype
Venom is a complex trait with substantial inter-and intraspecific variability resulting from
strong selective pressures acting on the expression of many toxic proteins. However …
strong selective pressures acting on the expression of many toxic proteins. However …
Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome
DD Almeida, VL Viala, PG Nachtigall… - Proceedings of the …, 2021 - National Acad Sciences
Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to
become part of the toxin arsenal is a significant evolutionary question. While this process …
become part of the toxin arsenal is a significant evolutionary question. While this process …
The roles of balancing selection and recombination in the evolution of rattlesnake venom
The origin of snake venom involved duplication and recruitment of non-venom genes into
venom systems. Several studies have predicted that directional positive selection has …
venom systems. Several studies have predicted that directional positive selection has …
Large-scale snake genome analyses provide insights into vertebrate development
Snakes are a remarkable squamate lineage with unique morphological adaptations,
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
especially those related to the evolution of vertebrate skeletons, organs, and sensory …
Why do some vertebrates have microchromosomes?
With more than 70,000 living species, vertebrates have a huge impact on the field of biology
and research, including karyotype evolution. One prominent aspect of many vertebrate …
and research, including karyotype evolution. One prominent aspect of many vertebrate …
The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom
MP Hogan, ML Holding, GS Nystrom… - Proceedings of the …, 2024 - National Acad Sciences
Developmental phenotypic changes can evolve under selection imposed by age-and size-
related ecological differences. Many of these changes occur through programmed …
related ecological differences. Many of these changes occur through programmed …
Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways
Understanding how regulatory mechanisms evolve is critical for understanding the
processes that give rise to novel phenotypes. Snake venom systems represent a valuable …
processes that give rise to novel phenotypes. Snake venom systems represent a valuable …