The rise of genomics in snake venom research: recent advances and future perspectives

W Rao, K Kalogeropoulos, ME Allentoft… - …, 2022 - academic.oup.com
Snake venoms represent a danger to human health, but also a gold mine of bioactive
proteins that can be harnessed for drug discovery purposes. The evolution of snakes and …

Snake venomics: fundamentals, recent updates, and a look to the next decade

CH Tan - Toxins, 2022 - mdpi.com
Venomic research, powered by techniques adapted from proteomics, transcriptomics, and
genomics, seeks to unravel the diversity and complexity of venom through which knowledge …

Functional genomic diversity is correlated with neutral genomic diversity in populations of an endangered rattlesnake

S Mathur, AJ Mason, GS Bradburd… - Proceedings of the …, 2023 - National Acad Sciences
Theory predicts that genetic erosion in small, isolated populations of endangered species
can be assessed using estimates of neutral genetic variation, yet this widely used approach …

Micro and macroevolution of sea anemone venom phenotype

EG Smith, JM Surm, J Macrander, A Simhi… - Nature …, 2023 - nature.com
Venom is a complex trait with substantial inter-and intraspecific variability resulting from
strong selective pressures acting on the expression of many toxic proteins. However …

Tracking the recruitment and evolution of snake toxins using the evolutionary context provided by the Bothrops jararaca genome

DD Almeida, VL Viala, PG Nachtigall… - Proceedings of the …, 2021 - National Acad Sciences
Venom is a key adaptive innovation in snakes, and how nonvenom genes were co-opted to
become part of the toxin arsenal is a significant evolutionary question. While this process …

The roles of balancing selection and recombination in the evolution of rattlesnake venom

DR Schield, BW Perry, RH Adams, ML Holding… - Nature ecology & …, 2022 - nature.com
The origin of snake venom involved duplication and recruitment of non-venom genes into
venom systems. Several studies have predicted that directional positive selection has …

Large-scale snake genome analyses provide insights into vertebrate development

C Peng, DD Wu, JL Ren, ZL Peng, Z Ma, W Wu, Y Lv… - Cell, 2023 - cell.com
Snakes are a remarkable squamate lineage with unique morphological adaptations,
especially those related to the evolution of vertebrate skeletons, organs, and sensory …

Why do some vertebrates have microchromosomes?

K Srikulnath, SF Ahmad, W Singchat, T Panthum - Cells, 2021 - mdpi.com
With more than 70,000 living species, vertebrates have a huge impact on the field of biology
and research, including karyotype evolution. One prominent aspect of many vertebrate …

The genetic regulatory architecture and epigenomic basis for age-related changes in rattlesnake venom

MP Hogan, ML Holding, GS Nystrom… - Proceedings of the …, 2024 - National Acad Sciences
Developmental phenotypic changes can evolve under selection imposed by age-and size-
related ecological differences. Many of these changes occur through programmed …

Snake venom gene expression is coordinated by novel regulatory architecture and the integration of multiple co-opted vertebrate pathways

BW Perry, SS Gopalan, GIM Pasquesi… - Genome …, 2022 - genome.cshlp.org
Understanding how regulatory mechanisms evolve is critical for understanding the
processes that give rise to novel phenotypes. Snake venom systems represent a valuable …