Autoimmune hepatitis is characterized by autoantibodies, hypergammaglobulinemia, and
interface hepatitis on histological examination. The features lack diagnostic specificity, and …

The induction of tolerance is a major goal of immunotherapy. Investigations over the last 20
years have shown that anti-CD3 monoclonal antibodies (mAbs) effectively treat autoimmune …

Abstract The neonatal Fc receptor (FcRn), also known as the Brambell receptor and
encoded by Fcgrt, is a MHC class I like molecule that functions to protect IgG and albumin …

Oral antigen administration to induce regulatory T cells (Treg) takes advantage of regulatory
mechanisms that the gastrointestinal tract utilizes to promote unresponsiveness against food …

Background—Accumulating evidence suggests that several subsets of regulatory T cells that
actively mediate immunologic tolerance play crucial roles in atherogenesis. Recently, orally …

Microglia play a key role in innate immunity in Alzheimer disease (AD), but their role as
antigen-presenting cells is as yet unclear. Here we found that amyloid β peptide (Aβ) …

Two humanized, anti-CD3 mAbs with reduced FcR binding, teplizumab and otelixizumab,
have been evaluated in over 1500 subjects, ages 7–45, with new and recently diagnosed …

Introduction Immunotherapies for type 1 diabetes mellitus (T1D) have been the focus of
intense research over the past few decades. Nevertheless, the results of clinical trials have …

Gut mucosal surfaces separate the external environment from the internal sterile
environment and so represent a first line of defence system. This barrier faces environments …

The immune system plays a role in the pathogenesis of non-alcoholic steatohepatitis
(NASH) underlying hepatocyte injury and fibrosis progression at all disease stages. Oral …