Sperm motility is linked to the activation of signaling pathways that trigger movement. These
pathways are mainly dependent on Ca2+, which acts as a secondary messenger. The …

Calcium is an essential ion which regulates sperm motility, capacitation and the acrosome
reaction (AR), three processes necessary for successful fertilization. The AR enables the …

In mammalian sperm cells, regulation of spatiotemporal Ca 2+ signaling relies on the
quadrilinear Ca 2+ signaling nanodomains in the flagellar membrane. The sperm-specific …

In one of the first examples of how mechanics can inform axonemal mechanism, Machin's
study in the 1950s highlighted that observations of sperm motility cannot be explained by …

Mammalian sperm acquire fertilization capacity in the female reproductive tract in a process
known as capacitation. During capacitation, sperm change their motility pattern (ie …

Progesterone and prostaglandin E1 are postulated to trigger the human sperm acrosome
reaction (AR). However, their reported efficacy is very variable which likely, in part, reflects …

To become fertile, mammalian sperm must undergo a series of biochemical and
physiological changes known as capacitation. These changes involve crosstalk between …

Species preservation depends on the success of fertilization. Sperm are uniquely equipped
to fulfill this task, and, although several mechanisms are conserved among species, striking …

Before fertilization, sperms adhere to oviductal epithelium cells, and only a restrictive
number of winner sperms can escape to reach the egg. To study the sperm escape behavior …

Simple Summary In this work, we addressed if the presence of exogenous bicarbonate
required for pig sperm capacitation, which is a necessary step to acquire fertilizing ability …