Biology of lung macrophages in health and disease
H Aegerter, BN Lambrecht, CV Jakubzick - Immunity, 2022 - cell.com
Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …
players in innate immunity and maintenance of lung homeostasis. Until recently, assessing …
Interleukin-33 (IL-33): A critical review of its biology and the mechanisms involved in its release as a potent extracellular cytokine
C Cayrol, JP Girard - Cytokine, 2022 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, is an alarmin cytokine with
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …
crucial roles in tissue homeostasis and repair, type 2 immunity, allergic and non-allergic …
Immune determinants of chronic sequelae after respiratory viral infection
The acute effects of various respiratory viral infections have been well studied, with
extensive characterization of the clinical presentation as well as viral pathogenesis and host …
extensive characterization of the clinical presentation as well as viral pathogenesis and host …
Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease
Epithelial cells are charged with protection at barrier sites, but whether this normally
beneficial response might sometimes become dysfunctional still needs definition. Here, we …
beneficial response might sometimes become dysfunctional still needs definition. Here, we …
[HTML][HTML] Lung remodeling regions in long-term coronavirus disease 2019 feature basal epithelial cell reprogramming
K Wu, Y Zhang, SR Austin, H Yin-Declue… - The American Journal of …, 2023 - Elsevier
Respiratory viruses, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2), can trigger chronic lung disease that persists and even progresses after expected …
2), can trigger chronic lung disease that persists and even progresses after expected …
A potent MAPK13-14 inhibitor prevents airway inflammation and mucus production
Common respiratory diseases continue to represent a major public health problem, and
much of the morbidity and mortality is due to airway inflammation and mucus production …
much of the morbidity and mortality is due to airway inflammation and mucus production …
Mitogen-activated protein kinase-guided drug discovery for post-viral and related types of lung disease
MJ Holtzman, Y Zhang, K Wu… - European Respiratory …, 2024 - Eur Respiratory Soc
Respiratory viral infections are a major public health problem, with much of their morbidity
and mortality due to post-viral lung diseases that progress and persist after the active …
and mortality due to post-viral lung diseases that progress and persist after the active …
Chloride channel accessory 1 gene deficiency causes selective loss of mucus production in a new pig model
SP Keeler, J Yantis, BJ Gerovac… - … of Physiology-Lung …, 2022 - journals.physiology.org
Morbidity and mortality of respiratory diseases are linked to airway obstruction by mucus but
there are still no specific, safe, and effective drugs to correct this phenotype. The need for …
there are still no specific, safe, and effective drugs to correct this phenotype. The need for …
TLR3-activated monocyte-derived dendritic cells trigger progression from acute viral infection to chronic disease in the lung
Acute infection is implicated as a trigger for chronic inflammatory disease, but the full basis
for this switch is uncertain. In this study, we examine this issue using a mouse model of …
for this switch is uncertain. In this study, we examine this issue using a mouse model of …
Aging and respiratory viral infection: from acute morbidity to chronic sequelae
The altered immune response in aged hosts play a vital role in contributing to their
increased morbidity and mortality during respiratory virus infections. The aged hosts display …
increased morbidity and mortality during respiratory virus infections. The aged hosts display …