Mitochondria are well known as organelles responsible for the maintenance of cellular
bioenergetics through the production of ATP. Although oxidative phosphorylation may be …

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell
death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain …

Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …

Severe SARS-CoV-2 infections are characterized by lymphopenia, but the mechanisms
involved are still elusive. Based on our knowledge of HIV pathophysiology, we hypothesized …

Dying cells have an important role in the initiation of CD8+ T cell-mediated immunity. The
cross-presentation of antigens derived from dying cells enables dendritic cells to present …

RIP1 and RIP3 kinases are central players in TNF-induced programmed necrosis. Here, we
report that the RIP homotypic interaction motifs (RHIMs) of RIP1 and RIP3 mediate the …

Abstract Receptor-interacting protein 1 (RIP1) kinase has emerged as a key upstream
regulator that controls inflammatory signalling as well as the activation of multiple cell death …

Apoptosis is a major form of cell death, characterized initially by a series of stereotypic
morphological changes. In the nematode Caenorhabditis elegans, the gene ced-3 encodes …

Receptor-interacting protein (RIP) kinases, in particular RIPK1, RIPK2 and RIPK3, have
emerged as pleiotropic modulators of inflammatory responses that act either by directly …

Necroptosis is a cellular mechanism of necrotic cell death induced by apoptotic stimuli in the
form of death domain receptor engagement by their respective ligands under conditions …