Ethanol is one of the most commonly abused drugs. Although environmental and genetic
factors contribute to the etiology of alcohol use disorders, it is ethanol's actions in the brain …

Beyond their well-established role as triggers for LTP and LTD of fast synaptic transmission
mediated by AMPA receptors, an expanding body of evidence indicates that NMDA …

Metaplasticity refers to the modification of plasticity induction (direction, magnitude, duration)
by previous activity of the same postsynaptic neuron or neuronal network. In recent years …

Adaptation of the nervous system to different chemical and physiologic conditions is
important for the homeostasis of brain processes and for learning and remembering …

Since its initial conceptualisation, metaplasticity has come to encompass a wide variety of
phenomena and mechanisms, creating the important challenge of understanding how they …

Alcoholism is associated with acute and long-term cognitive dysfunction including memory
impairment, resulting in substantial disability and cost to society. Thus, understanding how …

Drug addiction is driven, in part, by powerful drug-related memories. Deficits in social life,
particularly during adolescence, increase addiction vulnerability. Social isolation in rodents …

Cocaine, through its activation of dopamine (DA) signaling, usurps pathways that process
natural rewards. However, the extent to which there is overlap between the networks that …

Although the roles of dopaminergic signaling in learning and behavior are well established,
it is not fully understood how the activity of dopaminergic neurons is dynamically regulated …

Emerging evidence demonstrates that alcohol dependence is associated with dysregulation
of several neurotransmitters. Alterations in dopamine, glutamate and gamma-aminobutyric …