Oncolytic viruses represent a new class of therapeutic agents that promote anti-tumour
responses through a dual mechanism of action that is dependent on selective tumour cell …

Oncolytic virotherapy is an emerging treatment modality that uses replication-competent
viruses to destroy cancers. Recent advances include preclinical proof of feasibility for a …

Glioblastoma (GBM) is the most aggressive primary malignant brain cancer and urgently
requires effective treatments. Chimeric antigen receptor T (CAR-T) cell therapy offers a …

The life history of cancer cells encompasses a series of genetic missteps in which normal
cells are progressively transformed into tumor cells that invade surrounding tissues and …

Viruses as cancer therapies have attracted attention since the 19th century. Scientists
observation that viruses can preferentially lyse cancer cells rather than healthy cells, created …

Virotherapy is currently undergoing a renaissance, based on our improved understanding of
virus biology and genetics and our better knowledge of many different types of cancer …

There has long been interest in innovating an approach by which tumor cells can be
selectively and specifically targeted and destroyed. The discovery of viruses that lyse tumor …

In the search for novel cancer therapies that can be used in conjunction with existing
treatments, one promising area of research is the use of viral vectors and whole viruses. This …

Direct targeting of cancer cells with gene therapy has the potential to treat cancer on the
basis of its molecular characteristics. But although laboratory results have been extremely …

A large number of adenoviral agents are being developed for the treatment of cancer.
However, the treatment-related death of a patient with ornithine transcarbamylase deficiency …