New concepts in DNA methylation
A Jeltsch, RZ Jurkowska - Trends in biochemical sciences, 2014 - cell.com
The widely-cited model of maintenance of DNA methylation at CpG sites implies that DNA
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
methylation is introduced by the Dnmt3 de novo DNA methyltransferases during early …
[HTML][HTML] DNA methylation, its mediators and genome integrity
H Meng, Y Cao, J Qin, X Song, Q Zhang… - … journal of biological …, 2015 - ncbi.nlm.nih.gov
DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …
[PDF][PDF] The R882H DNMT3A mutation associated with AML dominantly inhibits wild-type DNMT3A by blocking its ability to form active tetramers
DA Russler-Germain, DH Spencer, MA Young… - Cancer cell, 2014 - cell.com
Somatic mutations in DNMT3A, which encodes a de novo DNA methyltransferase, are found
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
in∼ 30% of normal karyotype acute myeloid leukemia (AML) cases. Most mutations are …
Allosteric control of mammalian DNA methyltransferases–a new regulatory paradigm
A Jeltsch, RZ Jurkowska - Nucleic acids research, 2016 - academic.oup.com
In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
methyltransferases, which are all large multi-domain proteins containing a catalytic C …
Mammalian DNA methyltransferases: new discoveries and open questions
As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …
DNMT3A in Leukemia
L Brunetti, MC Gundry… - Cold Spring …, 2017 - perspectivesinmedicine.cshlp.org
DNA methylation is an epigenetic process involved in development, aging, and cancer.
Although the advent of new molecular techniques has enhanced our knowledge of how …
Although the advent of new molecular techniques has enhanced our knowledge of how …
DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
N Veland, Y Lu, S Hardikar, S Gaddis… - Nucleic acids …, 2019 - academic.oup.com
Abstract DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA
methyltransferase activity but regulates de novo DNA methylation. While biochemical …
methyltransferase activity but regulates de novo DNA methylation. While biochemical …
Driver mutations of cancer epigenomes
Epigenetic alterations are associated with all aspects of cancer, from tumor initiation to
cancer progression and metastasis. It is now well understood that both losses and gains of …
cancer progression and metastasis. It is now well understood that both losses and gains of …
A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells
SJ Kim, H Zhao, S Hardikar, AK Singh… - Blood, The Journal …, 2013 - ashpublications.org
Somatic heterozygous mutations of the DNA methyltransferase gene DNMT3A occur
frequently in acute myeloid leukemia and other hematological malignancies, with the …
frequently in acute myeloid leukemia and other hematological malignancies, with the …
[HTML][HTML] Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs
F Neri, A Krepelova, D Incarnato, M Maldotti, C Parlato… - Cell, 2013 - cell.com
The de novo DNA methyltransferase 3-like (Dnmt3L) is a catalytically inactive DNA
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …
methyltransferase that cooperates with Dnmt3a and Dnmt3b to methylate DNA. Dnmt3L is …