Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Micro RNA s (mi RNA s) are small non‐coding RNA s that regulate gene expression at a
post‐transcriptional level via either the degradation or translational repression of a target …

The aortic wall is composed of highly dynamic cell populations and extracellular matrix. In
response to changes in the biomechanical environment, aortic cells and extracellular matrix …

Wu et al The RAS and Cardiovascular Functions e109 homocysteine decreased
antihypertensive effect of enalapril, an ACE inhibitor, in chronic hypertensive patients. 61 …

Cardiometabolic and vascular disease, with their associated secondary complications, are
the leading cause of morbidity and mortality in Western society. Chronic inflammation is a …

Background: miRNA therapeutics have gained attention during the past decade. These
oligonucleotide treatments can modulate the expression of miRNAs in vivo and could be …

A variety of animal models have been developed to better understand the pathophysiology
of AAA. The 3 most commonly used mouse AAA models are adventitial exposure to calcium …

Abdominal aortic aneurysm (AAA) is a local dilatation of the abdominal aortic vessel wall
and is among the most challenging cardiovascular diseases as without urgent surgical …

Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

Background The protective effect of metformin (MET) on abdominal aortic aneurysm (AAA)
has been reported. However, the related mechanism is still poor understood. In this study …