There is a real consensus that new antibiotics are urgently needed and are the best chance
for combating antibiotic resistance. The phylum Actinobacteria is one of the main producers …

In this Review, we explore natural product antibiotics that do more than simply inhibit an
active site of an essential enzyme. We review these compounds to provide inspiration for the …

Streptomyces are a large and valuable resource of bioactive and complex secondary
metabolites, many of which have important clinical applications. With the advances in high …

Covering: up to 2022 Streptomyces are ubiquitous in terrestrial and marine environments,
where they display a fascinating metabolic diversity. As a result, these bacteria are a prolific …

The caseinolytic protease (ClpP) is part of a highly conserved proteolytic complex whose
disruption can lead to antibacterial activity but for which few specific inhibitors have been …

For centuries, natural products (NPs) have served as powerful therapeutics against a variety
of human ailments. Nowadays, they still represent invaluable resources for the treatment of …

Antimicrobial resistance to virtually all clinically applied antibiotic classes severely limits the
available options to treat bacterial infections. Hence, there is an urgent need to develop and …

Uropygial gland secretions of birds consist of host and bacteria derived compounds and
play a major sanitary and feather-protective role. Here we report on our microbiome studies …

Rising antibiotic resistance urgently calls for the discovery and evaluation of novel antibiotic
classes and unique antibiotic targets. The caseinolytic protease Clp emerged as an …

Covering: 2015 to 2022 In this review, we discuss the recent advances in the use of
isotopically labelled compounds to investigate the biosynthesis of polyketides, non …