An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Biological embedding occurs when life experience alters biological processes to affect later
life health and well-being. Although extensive correlative data exist supporting the notion …

Psychiatric disorders are complex multifactorial illnesses involving chronic alterations in
neural circuit structure and function as well as likely abnormalities in glial cells. While …

The acute stress response mobilizes energy to meet situational demands and re-establish
homeostasis. However, the underlying molecular cascades are unclear. Here, we use a brief …

Major depressive disorder (MDD) is a chronic, generally episodic and debilitating disease
that affects an estimated 300 million people worldwide, but its pathogenesis is poorly …

Depression is a common disorder that affects women at twice the rate of men. Here, we
report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory …

There is an urgent need for more effective medications to treat major depressive disorder, as
fewer than half of depressed patients achieve full remission and many are not responsive …

Psychosocial stress triggers a set of behavioral, neural, hormonal, and molecular responses
that can be a driving force for survival when adaptive and time-limited, but may also …

Depression is a devastating psychiatric disorder caused by a combination of genetic
predisposition and life events, mainly exposure to stress. Early life stress (ELS) in particular …

Major depressive disorder (MDD) is a chronic disease whose neurological basis and
pathophysiology remain poorly understood. Initially, it was proposed that genetic variations …