Native fluorescence, or autofluorescence (AF), consists in the emission of light in the UV-
visible, near-IR spectral range when biological substrates are excited with light at suitable …

This article presents an overview of time-resolved (lifetime) fluorescence techniques used in
biomedical diagnostics. In particular, we review the development of time-resolved …

Oral cancer is a significant health problem in the USA and throughout the world. Most oral
cancer patients are diagnosed at a late stage, when treatment is less successful and …

Traditional methods of screening for oral potentially malignant disorders and oral
malignancies involve a conventional oral examination with digital palpation. Evidence …

A clinically compatible fluorescence lifetime imaging microscopy (FLIM) system was
developed. The system was applied to intraoperative in vivo imaging of head and neck …

Diffuse reflectance spectroscopy (DRS) with a fiber-optic probe can noninvasively quantify
the optical properties of epithelial tissues and has shown the potential as a cost-effective …

Raman spectroscopy is an inelastic light scattering technique that is capable of probing
biochemical and biomolecular structures and conformations of tissue. This study aims to …

Actinic cheilitis is a potentially malignant disorder of the lips. Its first cause is believed to be
UV sun radiation. The lesion is highly heterogeneous, making the choice of area to be …

Examining the hemoglobin level of blood is an important way to achieve the diagnosis of
anemia, but it requires blood drawing and blood test. Examining the color distribution of …

Noninvasive medical procedures are usually preferable to their invasive counterparts in the
medical community. Anemia examining through the palpebral conjunctiva is a convenient …