Plasminogen activator inhibitor-1 in cancer: rationale and insight for future therapeutic testing
VR Placencio, YA DeClerck - Cancer research, 2015 - AACR
Despite its function as an inhibitor of urokinase and tissue-type plasminogen activator (PA),
PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting …
PA inhibitor-1 (PAI-1) has a paradoxical protumorigenic role in cancer, promoting …
[HTML][HTML] uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
MA Pavón, I Arroyo-Solera, MV Céspedes… - Oncotarget, 2016 - ncbi.nlm.nih.gov
There is strong evidence supporting the role of the plasminogen activator system in head
and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase …
and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase …
[HTML][HTML] Serpins promote cancer cell survival and vascular co-option in brain metastasis
Brain metastasis is an ominous complication of cancer, yet most cancer cells that infiltrate
the brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as …
the brain die of unknown causes. Here, we identify plasmin from the reactive brain stroma as …
[HTML][HTML] Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis
Tumor cells display progressive changes in metabolism that correlate with malignancy,
including development of a lipogenic phenotype. How stored fats are liberated and …
including development of a lipogenic phenotype. How stored fats are liberated and …
The role of tenascin-C in tissue injury and tumorigenesis
KS Midwood, G Orend - Journal of cell communication and signaling, 2009 - Springer
The extracellular matrix molecule tenascin-C is highly expressed during embryonic
development, tissue repair and in pathological situations such as chronic inflammation and …
development, tissue repair and in pathological situations such as chronic inflammation and …
Three decades of research on plasminogen activator inhibitor-1: a multifaceted serpin
PJ Declerck, A Gils - Seminars in thrombosis and hemostasis, 2013 - thieme-connect.com
Plasminogen activator inhibitor 1 (PAI-1) is the main inhibitor of tissue-type (t-PA) and
urokinase-type (u-PA) plasminogen activator and therefore plays an important role in the …
urokinase-type (u-PA) plasminogen activator and therefore plays an important role in the …
Role of microRNAs in lung development and pulmonary diseases
MicroRNAs (miRNAs) are a class of small noncoding RNA which exert post-transcriptional
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
gene regulation activity by targeting messenger RNAs. miRNAs have been found to be …
Key contribution of CPEB4-mediated translational control to cancer progression
E Ortiz-Zapater, D Pineda, N Martínez-Bosch… - Nature medicine, 2012 - nature.com
Malignant transformation, invasion and angiogenesis rely on the coordinated
reprogramming of gene expression in the cells from which the tumor originated. Although …
reprogramming of gene expression in the cells from which the tumor originated. Although …
Histopathological features of cancer-associated venous thromboembolism: presence of intrathrombus cancer cells and prothrombotic factors
T Gi, A Kuwahara, A Yamashita, S Matsuda… - … and Vascular Biology, 2023 - Am Heart Assoc
Background: Cancer-associated venous thromboembolism (VTE) is a critical complication in
patients with cancer. However, the pathological findings of VTE are limited. Here, we …
patients with cancer. However, the pathological findings of VTE are limited. Here, we …