It has been more than 100 years since Paul Ehrlich reported that various water-soluble dyes
injected into the circulation did not enter the brain. Since Ehrlich's first experiments, only a …

Therapeutic options for neurological disorders currently remain limited. The intrinsic
complexity of the brain architecture prevents potential therapeutics from reaching their …

Brain endothelial cells form a paracellular and transcellular barrier to many blood-borne
solutes via tight junctions (TJs) and scarce endocytotic vesicles. The blood-brain barrier …

Like cardiovascular disease and cancer, neurological disorders present an increasing
challenge for an ageing population. Whereas nonpharmacological procedures are routine …

The purpose of this study was to test the hypothesis that burst ultrasound in the presence of
an ultrasound contrast agent can disrupt the blood–brain barrier (BBB) with acoustic …

Alzheimer's disease (AD) is the most common cause of dementia among the elderly,
affecting 5% of Americans over age 65, and 20% over age 80. An excess of senile plaques …

Background The endothelial cells that form the lumen of capillaries and microvessels are an
important component of the blood–brain barrier. Cell phenotype is regulated by transducing …

The central nervous system (CNS) is a perfectly regulated environment with conditions far
different from those in the rest of the organism. Even slight changes in this machinery affect …

Background: The blood–brain barrier acts as a highly regulated interface; its dysfunction
may exacerbate, and perhaps initiate, neurological and neuropsychiatric disorders …

Brain edema continues to be a major cause of mortality after diverse types of brain
pathologies such as major cerebral infarcts, hemorrhages, trauma, infections and tumors …