MicroRNAs (miRNAs) are a conserved class of small non-coding RNAs that assemble with
Argonaute proteins into miRNA-induced silencing complexes (miRISCs) to direct post …

Since their discovery 20 years ago, miRNAs have attracted much attention from all areas of
biology. These short (∼ 22 nt) non-coding RNA molecules are highly conserved in evolution …

Since their discovery almost two decades ago, microRNAs (miRNAs) have been shown to
function by post-transcriptionally regulating protein accumulation. Understanding how …

Despite their widespread roles as regulators of gene expression, important questions
remain about target regulation by microRNAs. Animal microRNAs were originally thought to …

Mammalian circadian rhythms are synchronized to the external time by daily resetting of the
suprachiasmatic nucleus (SCN) in response to light. As the master circadian pacemaker, the …

MicroRNAs (miRNAs) play critical roles in a variety of biological processes through
widespread effects on protein synthesis. Upon association with the miRNA-induced …

GW182 family proteins interact with Argonaute proteins and are required for the translational
repression, deadenylation and decay of miRNA targets. To elicit these effects, GW182 …

GW182 family proteins are essential for microRNA-mediated gene silencing in animal cells.
They are recruited to miRNA targets through direct interactions with Argonaute proteins and …

The PABP family of proteins were originally thought of as a simple shield for the mRNA poly
(A) tail. Years of research have shown that PABPs interact not only with the poly (A) tail, but …

Animal miRNAs silence the expression of mRNA targets through translational repression,
deadenylation and subsequent mRNA degradation. Silencing requires association of …