The diversity inherent in biological systems has its roots in genetic variation but is revealed
through distinctions in the molecular profile and thus the identity of individual cells. The …

The general mechanisms that control the cell cycle in mammalian cells have been studied in
depth and several proteins that are involved in the tight regulation of cell cycle progression …

Cyclin E, one of the activators of the cyclin-dependent kinase Cdk2, is expressed near the
G1–S phase transition and is thought to be critical for the initiation of DNA replication and …

During Drosophila development and mammalian embryogenesis, exit from the cell cycle is
contingent on tightly controlled downregulation of the activity of Cyclin E–Cdk2 complexes …

In Drosophila, the development of the compound eye depends on the movement of a
morphogenetic furrow (MF) from the posterior (P) to the anterior (A) of the eye imaginal disc …

The transforming growth factor β (TGF-β) family signaling pathway is conserved and
ubiquitous in animals. In Drosophila, fewer representatives of each signaling component are …

Transplantation experiments have shown that developing metazoan organs carry intrinsic
information about their size and shape. Organ and body size are also sensitive to extrinsic …

The number of cells in developing organs must be controlled spatially by extracellular
signals. Our results show how cell number can be regulated by cell interactions controlling …

The Drosophila signaling factor decapentaplegic (dpp) mediates the effects of hedgehog
(hh) in tissue patterning by regulating the expression of tissue-specific genes. In the eye …

Spatially and temporally choreographed cell cycles accompany the differentiation of the
Drosophila retina. The extracellular signals that control these patterns have been identified …