Abstract Triple Negative Breast Cancer (TNBC) is the most lethal subtype of breast cancer.
Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy …

Diacylglycerol (DAG) is a lipid second messenger that is generated in response to
extracellular stimuli and channels intracellular signals that affect mammalian cell …

Sex differences in coronary artery disease (CAD) presentation, risk factors and prognosis
have been widely studied. Similarly, studies on atherosclerosis have shown prominent sex …

The sorting and distribution to different final destinations of roughly a third of the membrane
and secreted proteins occurs at the level of the trans‐Golgi network (TGN). This TGN …

Few kinases have been studied as extensively as protein kinase C (PKC), particularly in the
context of cancer. As major cellular targets for the phorbol ester tumor promoters and …

Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the
signaling network of the second messenger diacylglycerol. The three family members …

Protein kinase D is a family of evolutionarily conserved serine/threonine kinases that
belongs to the Ca++/Calmodulin-dependent kinase superfamily. Signal transduction …

Pancreatic cancer (PC) is one of the highly aggressive malignancies in the United States. It
has been shown that multiple signaling pathways are involved in the pathogenesis of PC …

Protein kinase D (PKD) family members play controversial roles in prostate cancer (PC).
Thus, PKD1 is nearly absent in advanced tumours, where PKD2 and PKD3 are upregulated …

The protein kinase D (PKD) family of proteins are important regulators of tumor growth,
development, and progression. CRT0066101, an inhibitor of PKD, has antitumor activity in …