Epithelial-to-mesenchymal transition (EMT) mechanism is responsible for metastasis and
migration of cancer cells to neighboring cells and tissues. Morphologically, epithelial cells …

The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to
inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial …

Transforming growth factor-β (TGF-β) signaling triggers diverse biological actions in
inflammatory diseases. In tissue fibrosis, it acts as a key pathogenic regulator for promoting …

Prostate cancer is among most malignant tumors around the world and this urological tumor
can be developed as result of genomic mutations and their accumulation during progression …

Aims This study aims to explore the function and mechanism of G Protein-coupled receptor
class C group 5 member A (GPRC5A) in docetaxel-resistance and liver metastasis of breast …

Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in
embryonic development, wound-healing, and immune homeostasis. Yet, during tumor …

Transforming growth factor-beta (TGF-β) is a member of a family of secreted cytokines with
vital biological functions in cells. The abnormal expression of TGF-β signaling is a common …

Advanced prostate cancer (PCa) often develops bone metastasis, for which therapies are
very limited and the underlying mechanisms are poorly understood. We report that bone …

Background Docetaxel has been approved by USFDA as a first-line treatment for castration-
resistant prostate cancer (CRPC) patients. Patients receiving androgen deprivation therapy …

Tumours are complex systems with dynamic interactions between tumour cells, non-tumour
cells, and extracellular components that comprise the tumour microenvironment (TME). The …