Synthesis and antioxidant investigation of Ag2S nanoparticles obtained from silver (I) complex of N-methyl-N-phenyl-dithiocarbamate

TO Ajiboye, DC Onwudiwe - Journal of Nano Research, 2022 - Trans Tech Publ
Monoclinic Ag 2 S nanoparticles have been synthesized via a thermal decomposition of Ag
(I) complex of N-methyl-N-phenyl dithiocarbamate (as a single source precursor) in …

Pentacycloundecane derived hydroxy acid peptides: a new class of irreversible non-scissile ether bridged type isoster as potential HIV-1 wild type C-SA protease …

R Karpoormath, Y Sayed, P Govender, T Govender… - Bioorganic …, 2012 - Elsevier
Novel peptides incorporating the PCU derived hydroxy acid (5-hydroxy-4-oxahexacyclo [5.4.
1.02, 6.03, 10.05, 9.08, 11] dodecane) were synthesized and their activity against the …

Pentacycloundecane‐diol‐Based HIV‐1 Protease Inhibitors: Biological Screening, 2D NMR, and Molecular Simulation Studies

B Honarparvar, MM Makatini, SA Pawar… - …, 2012 - Wiley Online Library
Novel compounds incorporating a pentacycloundecane (PCU) diol moiety were designed,
synthesized, and evaluated as inhibitors of the wild‐type C‐South African (C‐SA) HIV‐1 …

Synthesis, screening and computational investigation of pentacycloundecane-peptoids as potent CSA-HIV PR inhibitors

MM Makatini, K Petzold, PI Arvidsson… - European journal of …, 2012 - Elsevier
Herein, we present the first pentacycloundecane (PCU) diol peptoid derived HIV protease
inhibitors with IC50 values ranging from 6.5 to 0.075 μM. Five derivatives were synthesized …

Serendipitous discovery of new pentacycloundecane molecules

MT Kelani, HG Kruger, T Govender… - Journal of molecular …, 2020 - Elsevier
This study explored the rearrangement process which occurred during Grignard reactions of
the pentacycloundecane (PCU) dione, 1. This compound was reacted with vinyl and allyl …

Novel linear diamine disubstituted polycyclic 'cage'derivatives as potential antimycobacterial candidates

OK Onajole, S Sosibo, P Govender… - Chemical biology & …, 2011 - Wiley Online Library
As a part of an ongoing project to develop highly potent antituberculosis therapeutics, a
series novel polycyclic 'cage'tetra‐amines were synthesized and screened for in‐vitro …

Preparation and complete 1 H and 13C assignment of some pentacyclo[5.4.0.02,6.03,10.05,9]undecane‐8,11‐dione (PCUD) derivatives

AM Kenwright, JD Sellars - Magnetic Resonance in Chemistry, 2012 - Wiley Online Library
The preparation of a number of alkyl and alkoxy derivatives of pentacyclo [5.4. 0.02, 6.03,
10.05, 9] undecane‐8, 11‐dione derivatives utilising a cheap, practical, low energy,'green' …

Novel PCU cage diol peptides as potential targets against wild-type CSA HIV-1 protease: synthesis, biological screening and molecular modelling studies

R Karpoormath, Y Sayed, T Govender… - Medicinal Chemistry …, 2013 - Springer
We have synthesized a series of novel pentacycloundecane cage diol diacid (PCU diol
diacid) incorporated C 2-symmetric peptides. Their activity against the resistance-prone wild …

Trends in nmr structural elucidation of polycyclic cages, namely: Adamantane, pentacycloundecane and trishomocubane

MT Kelan, D Dieudonné, KJ Skowron, C Pedigo… - South African Journal of …, 2021 - ajol.info
Abstract Advances in Nuclear Magnetic Resonance (NMR) spectroscopy is a cornerstone in
structure elucidation of polycyclic 'cage'scaffolds. Due to the compactness of these …

Synthesis and NMR elucidation of pentacycloundecane-derived hydroxy acid peptides as potential anti-HIV-1 agents

R Karpoormath, F Albericio, T Govender… - Structural Chemistry, 2013 - Springer
The synthesis and NMR elucidation of eight novel peptides incorporating the
pentacycloundecane (PCU)-derived hydroxy acid are reported. The PCU cage amino acids …