The retinal pigment epithelium (RPE), a monolayer of post-mitotic polarized epithelial cells,
strategically situated between the photoreceptors and the choroid, is the primary caretaker of …

Usher syndrome (USH), clinically and genetically heterogeneous, is the leading genetic
cause of combined hearing and vision loss. USH is classified into three types, based on the …

Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

Retinal pigment epithelial cells (RPE) constitute a simple layer of cuboidal cells that are
strategically situated behind the photoreceptor (PR) cells. The inconspicuousness of this …

Tissue-resident phagocytes are responsible for the routine binding, engulfment, and
resolution of their meals. Such populations of cells express appropriate surface receptors …

Photoreceptor cells maintain a roughly constant length by continuously generating new
outer segments from their base while simultaneously releasing mature outer segments …

Age-related macular degeneration (AMD) is a disease that affects the macula–the central
part of the retina. It is a leading cause of irreversible vision loss in the elderly. AMD onset is …

Age-related macular degeneration (AMD) is a complex, degenerative and progressive eye
disease that usually does not lead to complete blindness, but can result in severe loss of …

Maintenance of protein homeostasis, also referred to as “Proteostasis”, integrates multiple
pathways that regulate protein synthesis, folding, translocation, and degradation. Failure in …

Blindness, although not life threatening, is a debilitating disorder for which few, if any
treatments exist. Ocular gene therapies have the potential to profoundly improve the quality …