[HTML][HTML] A snapshot of the PD-1/PD-L1 pathway
Cancer cells can evade the attack from host immune systems via hijacking the regulatory
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …
circuits mediated by immune checkpoints. Therefore, reactivating the antitumor immunity by …
Anti–PD-1/PD-L1 therapy of human cancer: past, present, and future
Major progress has been made toward our understanding of the programmed death-
1/programmed death ligand-1 (PD-1/PD-L1) pathway (referred to as the PD pathway). mAbs …
1/programmed death ligand-1 (PD-1/PD-L1) pathway (referred to as the PD pathway). mAbs …
CTLA-4: From mechanism to autoimmune therapy
A Hosseini, T Gharibi, F Marofi, Z Babaloo… - International …, 2020 - Elsevier
CD28 and CTLA-4 are both important stimulatory receptors for the regulation of T cell
activation. Because receptors share common ligands, B7. 1 and B7. 2, the expression and …
activation. Because receptors share common ligands, B7. 1 and B7. 2, the expression and …
The yin and yang of co-inhibitory receptors: toward anti-tumor immunity without autoimmunity
Co-inhibitory receptors are important regulators of T-cell function that define the balance
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …
between tolerance and autoimmunity. The immune regulatory function of co-inhibitory …
Co-stimulatory and co-inhibitory pathways in autoimmunity
Q Zhang, DAA Vignali - Immunity, 2016 - cell.com
The immune system is guided by a series of checks and balances, a major component of
which is a large array of co-stimulatory and co-inhibitory pathways that modulate the host …
which is a large array of co-stimulatory and co-inhibitory pathways that modulate the host …
[HTML][HTML] Treg and CTLA-4: two intertwining pathways to immune tolerance
LSK Walker - Journal of autoimmunity, 2013 - Elsevier
Both the CTLA-4 pathway and regulatory T cells (Treg) are essential for the control of
immune homeostasis. Their therapeutic relevance is highlighted by the increasing use of …
immune homeostasis. Their therapeutic relevance is highlighted by the increasing use of …
Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4
T Takahashi, T Tagami, S Yamazaki, T Uede… - The Journal of …, 2000 - rupress.org
This report shows that cytotoxic T lymphocyte–associated antigen 4 (CTLA-4) plays a key
role in T cell–mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for …
role in T cell–mediated dominant immunologic self-tolerance. In vivo blockade of CTLA-4 for …
Current understanding of CTLA-4: from mechanism to autoimmune diseases
MM Hossen, Y Ma, Z Yin, Y Xia, J Du… - Frontiers in …, 2023 - frontiersin.org
Autoimmune diseases (ADs) are characterized by the production of autoreactive
lymphocytes, immune responses to self-antigens, and inflammation in related tissues and …
lymphocytes, immune responses to self-antigens, and inflammation in related tissues and …
Cytotoxic T Lymphocyte–Associated Antigen 4 Plays an Essential Role in the Function of Cd25+Cd4+ Regulatory Cells That Control Intestinal Inflammation
S Read, V Malmström, F Powrie - The Journal of experimental medicine, 2000 - rupress.org
It is now clear that functionally specialized regulatory T (Treg) cells exist as part of the
normal immune repertoire, preventing the development of pathogenic responses to both self …
normal immune repertoire, preventing the development of pathogenic responses to both self …
B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes
B Salomon, DJ Lenschow, L Rhee, N Ashourian… - Immunity, 2000 - cell.com
CD28/B7 costimulation has been implicated in the induction and progression of autoimmune
diseases. Experimentally induced models of autoimmunity have been shown to be …
diseases. Experimentally induced models of autoimmunity have been shown to be …