Opioid use disorder (OUD) is a chronic relapsing disorder that, whilst initially driven by
activation of brain reward neurocircuits, increasingly engages anti-reward neurocircuits that …

Drug consumption is driven by a drug's pharmacological effects, which are experienced as
rewarding, and is influenced by genetic, developmental, and psychosocial factors that …

This guideline provides recommendations for clinicians providing pain care, including those
prescribing opioids, for outpatients aged≥ 18 years. It updates the CDC Guideline for …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Treatment of Opioid-Use Disorders | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …

What is known and objective Opioid use in the United States has reached unprecedented—
some would even say crisis—levels. Although many individuals use opioid drugs as part of …

Background and Objectives The opioid crisis has taken an immense toll in the United States.
On average, five lives are lost to an opioid overdose every hour of the day; estimated costs …

We have recently shown that damage to the insula leads to a profound disruption of
addiction to cigarette smoking (Naqvi et al., Science 315: 531–534, 2007). Yet, there is little …

Increasing concern about the risks and limited evidence supporting the therapeutic benefit of
long-term opioid therapy for chronic noncancer pain are leading prescribers to consider …

Background The pandemic of coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as one of the biggest …