Replication protein A [RPA; also known as replication factor A (RFA) and human single-
stranded DNA-binding protein] is a single-stranded DNA-binding protein that is required for …

DNA helicases are ubiquitous molecular motor proteins which harness the chemical free
energy of ATP hydrolysis to catalyze the unwinding of energetically stable duplex DNA, and …

The human premature aging disorder Werner syndrome (WS) is associated with a large
number of symptoms displayed in normal aging. The WRN gene product, a DNA helicase …

Background Strains with increased alkali tolerance have a broad application in industrial,
especially for bioremediation, biodegradation, biocontrol and production of bio-based …

Initiation sites for DNA synthesis in the chromosomal autonomously replicating sequence
(ARS) 1 of Saccharomyces cerevisiae were detected at the nucleotide level. The transition …

Mini-chromosome Maintenance (MCM) proteins play an essential role in both initiation and
elongation phases of DNA replication in Eukarya. Genes encoding MCM homologs are …

Background Termination of translation in eukaryotes is controlled by two interacting
polypeptide chain release factors, eRFl and eRF3. eRFl recognizes nonsense codons UAA …

The TOR proteins, originally identified as targets of the immunosuppressant rapamycin,
contain an ATM-like “lipid kinase” domain and are required for early G1 progression in …

Translation termination is the final step that completes the synthesis of a polypeptide.
Premature translation termination by introduction of a nonsense mutation leads to the …

Herpes simplex virus type-1 UL9 protein is a sequence-specific DNA-binding protein that
recognizes elements in the viral origins of DNA replication and possesses DNA helicase …