Current approaches and challenges for the metabolite profiling of complex natural extracts
Metabolite profiling is critical in many aspects of the life sciences, particularly natural product
research. Obtaining precise information on the chemical composition of complex natural …
research. Obtaining precise information on the chemical composition of complex natural …
Dereplication strategies in natural product research: How many tools and methodologies behind the same concept?
J Hubert, JM Nuzillard, JH Renault - Phytochemistry Reviews, 2017 - Springer
The development of new drugs will certainly benefit from an ever improving knowledge of
the living beings chemistry. However, identification of drugable molecules within the …
the living beings chemistry. However, identification of drugable molecules within the …
Molecular networking as a dereplication strategy
JY Yang, LM Sanchez, CM Rath, X Liu… - Journal of natural …, 2013 - ACS Publications
A major goal in natural product discovery programs is to rapidly dereplicate known entities
from complex biological extracts. We demonstrate here that molecular networking, an …
from complex biological extracts. We demonstrate here that molecular networking, an …
Natural product isolation–how to get from biological material to pure compounds
F Bucar, A Wube, M Schmid - Natural product reports, 2013 - pubs.rsc.org
Covering: 2008 to 2012Since the last comprehensive review by Otto Sticher on natural
product isolation in NPR (O. Sticher, Nat. Prod. Rep., 2008, 25, 517), a plethora of new …
product isolation in NPR (O. Sticher, Nat. Prod. Rep., 2008, 25, 517), a plethora of new …
Concepts and methods to access novel antibiotics from actinomycetes
Actinomycetes have been proven to be an excellent source of secondary metabolites for
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
more than half a century. Exhibiting various bioactivities, they provide valuable approved …
Applications of nuclear magnetic resonance in lipid analyses: An emerging powerful tool for lipidomics studies
The role of lipids in cell, tissue, and organ physiology is crucial; as many diseases, including
cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to …
cancer, diabetes, neurodegenerative, and infectious diseases, are closely related to …
Current status and contemporary approaches to the discovery of antitumor agents from higher plants
G Agarwal, PJB Carcache, EM Addo… - Biotechnology advances, 2020 - Elsevier
Higher plant constituents have afforded clinically available anticancer drugs. These include
both chemically unmodified small molecules and their synthetic derivatives currently used or …
both chemically unmodified small molecules and their synthetic derivatives currently used or …
NMR technique and methodology in botanical health product analysis and quality control
Botanicals have played an important role in maintaining human health and well-being
throughout history. During the past few decades in particular, the use of botanical health …
throughout history. During the past few decades in particular, the use of botanical health …
Edible seaweed as future functional food: Identification of α-glucosidase inhibitors by combined use of high-resolution α-glucosidase inhibition profiling and HPLC …
Crude chloroform, ethanol and acetone extracts of nineteen seaweed species were
screened for their antioxidant and α-glucosidase inhibitory activity. Samples showing more …
screened for their antioxidant and α-glucosidase inhibitory activity. Samples showing more …
Mass spectrometry and NMR spectroscopy: modern high-end detectors for high resolution separation techniques–state of the art in natural product HPLC-MS, HPLC …
C Seger, S Sturm, H Stuppner - Natural product reports, 2013 - pubs.rsc.org
Covering: 2005 to 2013Current natural product research is unthinkable without the use of
high resolution separation techniques as high performance liquid chromatography or …
high resolution separation techniques as high performance liquid chromatography or …