The zebrafish has become a prominent vertebrate model for disease and has already
contributed to several examples of successful phenotype-based drug discovery. For the …

Components from venoms have stimulated many drug discovery projects, with some notable
successes. These are briefly reviewed, from captopril to ziconotide. However, there have …

Originally designed as an alternative for the acute fish toxicity test according to, eg, OECD
TG 203, the fish embryo test (FET) with the zebrafish (Danio rerio) has been optimized …

Although small interfering RNA (siRNA) holds great therapeutic promise, its delivery to the
disease site remains a paramount obstacle. In this study, we tested whether brain …

In the past 2 decades, it has become evident that individuals born with congenital heart
disease (CHD) are at risk of developing life-long neurological deficits. Multifactorial risk …

Animal models of cardiovascular disease are key players in the translational medicine
pipeline used to define the conserved genetic and molecular basis of disease. Congenital …

Environmental pollution is a serious problem of the modern world that possesses a major
threat to public health. Exposure to environmental pollutants during embryonic development …

The use of zebrafish larvae in basic and applied research has grown exponentially during
the last 20 years. The reasons for this success lay in its specific experimental advantages …

Angiogenesis is the process through which new blood vessels are formed from preexisting
ones and plays a critical role in several conditions including embryonic development, tissue …

Human ageing is a fundamental biological process that leads to functional decay, increased
risk for various diseases and, ultimately, death. Some of the basic biological mechanisms …