CAR-T lymphocyte-based cell therapies; mechanistic substantiation, applications and biosafety enhancement with suicide genes: new opportunities to melt side …
P Ercilla-Rodríguez, M Sánchez-Díez… - Frontiers in …, 2024 - frontiersin.org
Immunotherapy has made significant strides in cancer treatment with strategies like
checkpoint blockade antibodies and adoptive T cell transfer. Chimeric antigen receptor T …
checkpoint blockade antibodies and adoptive T cell transfer. Chimeric antigen receptor T …
cDC2 plasticity and acquisition of a DC3‐like phenotype mediated by IL‐6 and PGE2 in a patient‐derived colorectal cancer organoids model
B Subtil, IAE van der Hoorn… - European Journal of …, 2024 - Wiley Online Library
Metastatic colorectal cancer (CRC) is highly resistant to therapy and prone to recur. The
tumor‐induced local and systemic immunosuppression allows cancer cells to evade …
tumor‐induced local and systemic immunosuppression allows cancer cells to evade …
EP2/EP4 targeting prevents tumor-derived PGE2-mediated immunosuppression in cDC2s
J Cuenca-Escalona, J Bödder, B Subtil… - Journal of Leukocyte …, 2024 - academic.oup.com
Tumor-derived prostaglandin E2 (PGE2) impairs antitumor immunity by priming suppressive
functions on various immune cell types, including dendritic cells (DCs). In this way, tumors …
functions on various immune cell types, including dendritic cells (DCs). In this way, tumors …