The tripeptide glutathione is the thiol compound present in the highest concentration in cells
of all organs. Glutathione has many physiological functions including its involvement in the …

There is significant evidence that the pathogenesis of several neurodegenerative diseases,
including Parkinson's disease, Alzheimer's disease, Friedreich's ataxia and amyotrophic …

Psychosocial stress has profound effects on the body, including the immune system and the
brain,. Although a large number of pre-clinical and clinical studies have linked peripheral …

Postembedding immunogold labeling was used to determine the relationship between
AMPA and NMDA receptor density and size of Schaffer collateral–commissural (SCC) …

Current concepts of the cause of Parkinson's disease (PD) suggest a role for both genetic
and environmental influences. Common to a variety of potential causes of nigral cell …

The water permeability of cell membranes differs by orders of magnitude, and most of this
variability reflects the differential expression of aquaporin water channels. We have recently …

Postembedding immunogold labeling was used to examine the subcellular distribution of
the inwardly rectifying K+ channel Kir4. 1 in rat retinal Müller cells and to compare this with …

Depletion of reduced glutathione occurs in the substantia nigra in Parkinson's disease and
in incidental Lewy body disease (presymptomatic Parkinson's disease) which may implicate …

Significance: Over the past several years, oxidative post-translational modifications of
protein cysteines have been recognized for their critical roles in physiology and …

Compartmentalization of brain ascorbate and glutathione between neurons and glia has
been a source of controversy. To address this question, we determined the ascorbate and …