The metabolic face of migraine—from pathophysiology to treatment

EC Gross, M Lisicki, D Fischer, PS Sándor… - Nature Reviews …, 2019 - nature.com
Migraine can be regarded as a conserved, adaptive response that occurs in genetically
predisposed individuals with a mismatch between the brain's energy reserve and workload …

Role of neuroinflammation and blood-brain barrier permutability on migraine

G Yamanaka, S Suzuki, N Morishita… - International journal of …, 2021 - mdpi.com
Currently, migraine is treated mainly by targeting calcitonin gene-related peptides, although
the efficacy of this method is limited and new treatment strategies are desired …

Microglial NLRP3 inflammasome activation mediates IL-1β release and contributes to central sensitization in a recurrent nitroglycerin-induced migraine model

W He, T Long, Q Pan, S Zhang, Y Zhang… - Journal of …, 2019 - Springer
Background Central sensitization is an important mechanism of chronic migraine (CM) and
is related to the inflammatory response of microglia. The NOD-like receptor protein 3 …

Vitamin D in migraine headache: a comprehensive review on literature

Z Ghorbani, M Togha, P Rafiee, ZS Ahmadi… - Neurological …, 2019 - Springer
Introduction As a primary headache, migraine has been established as the first leading
disability cause worldwide in the subjects who aged less than 50 years. A variety of dietary …

Oxidative stress and decreased thiol level in patients with migraine: cross-sectional study

Y Eren, E Dirik, S Neşelioğlu, Ö Erel - Acta Neurologica Belgica, 2015 - Springer
Although migraine is a neurological disorder known since long, its physiopathology remains
unclear. Recent studies suggest that migraine is associated with oxidative stress; however …

Potential protective mechanisms of ketone bodies in migraine prevention

EC Gross, RJ Klement, J Schoenen, DP D'Agostino… - Nutrients, 2019 - mdpi.com
An increasing amount of evidence suggests that migraines are a response to a cerebral
energy deficiency or oxidative stress levels that exceed antioxidant capacity. The ketogenic …

An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study

M Togha, S Razeghi Jahromi, Z Ghorbani, A Ghaemi… - BMC neurology, 2019 - Springer
Background In recent years, the role of neuroinflammation and oxidative stress in migraine
pathogenesis has achieved considerable interest; however, to date findings are equivocal …

Mitochondrial function and oxidative stress markers in higher-frequency episodic migraine

EC Gross, N Putananickal, AL Orsini, DR Vogt… - Scientific Reports, 2021 - nature.com
Increasing evidence points towards the role of mitochondrial functioning, energy
metabolism, and oxidative stress in migraine. However not all previous research has been …

Platelets and migraine

E Danese, M Montagnana, G Lippi - Thrombosis research, 2014 - Elsevier
The pathogenesis of migraine, the third most frequent disease worldwide, is complex and
multifaceted. Recent evidence suggests that this condition should be considered as a …

Serum vitamin D status in a group of migraine patients compared with healthy controls: a case–control study

M Togha, S Razeghi Jahromi… - … : The Journal of …, 2018 - Wiley Online Library
Objective The association between serum vitamin D and migraine is investigated in this
research. s Background Although the pathogenesis of migraine headache is not fully …