The nanoindentation has proved to be a most promising technique in the investigation of the
bone at the level of individual osteons and lamellae. It provides the nanomechanical …

Bone fractures commonly repair by forming a bridging structure called callus, which begins
as soft tissue and gradually ossifies to restore rigidity to the bone. Virtual mechanical testing …

Tissue engineering has recently gained popularity as an alternative to autografts to stimulate
bone tissue regeneration through structures called scaffolds. Most of the in vivo experiments …

The distraction osteogenesis has been an integrated treatment approach in significant bone
deficiencies resulting from debridement or high-energy trauma. Nevertheless, it usually …

BACKGROUND: 3D-printed bioceramic scaffolds have gained popularity due to their
controlled microarchitecture and their proven biocompatibility. However, their high …

The data-driven methodology with application to continuum mechanics relies upon two main
pillars:(i) experimental characterization of stress–strain pairs associated to different loading …

We present a computational model that integrates mechanobiological regulations,
angiogenesis simulations and models natural callus development to simulate bone fracture …

Bone lengthening and bone transport are regeneration processes that commonly rely on
distraction osteogenesis, a widely accepted surgical procedure to deal with numerous bony …

Introduction Woven bone, a heterogeneous and temporary tissue in bone regeneration, is
remodeled by osteoblastic and osteoclastic activity and shaped by mechanical stress to …

During recent years, many efforts have been made to increase the efficiency of the treatment
methods by adjusting the treatment with the specification of related tissue. Non-penetrating …