Roles of palmitoleic acid and its positional isomers, hypogeic and sapienic acids, in inflammation, metabolic diseases and cancer

MA Bermúdez, L Pereira, C Fraile, L Valerio… - Cells, 2022 - mdpi.com
In the last few years, the monounsaturated hexadecenoic fatty acids are being increasingly
considered as biomarkers of health with key functions in physiology and pathophysiology …

The role of omics in the pathophysiology, diagnosis and treatment of non-alcoholic fatty liver disease

N Perakakis, K Stefanakis, CS Mantzoros - Metabolism, 2020 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a multifaceted metabolic disorder, whose
spectrum covers clinical, histological and pathophysiological developments ranging from …

The role of hepatic lipid composition in obesity‐related metabolic disease

SA Willis, SJ Bawden, S Malaikah… - Liver …, 2021 - Wiley Online Library
Obesity is a primary antecedent to non‐alcoholic fatty liver disease whose cardinal feature is
excessive hepatic lipid accumulation. Although total hepatic lipid content closely associates …

Role of hepatic lipid species in the progression of nonalcoholic fatty liver disease

KQ Deng, X Huang, F Lei, XJ Zhang… - … of Physiology-Cell …, 2022 - journals.physiology.org
Nonalcoholic fatty liver disease (NAFLD) has become the most common liver disease due to
the global pandemic of metabolic diseases. Dysregulation of hepatic lipid metabolism plays …

Advance of serum biomarkers and combined diagnostic panels in nonalcoholic fatty liver disease

Y Zeng, H He, Z An - Disease Markers, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) affects approximately 25‐30% population
worldwide, which progresses from simple steatosis to nonalcoholic steatohepatitis (NASH) …

[PDF][PDF] Reduction in gut‐derived MUFAs via intestinal stearoyl‐CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma

S Ducheix, E Piccinin, C Peres… - Hepatology …, 2022 - Wiley Online Library
Nonalcoholic fatty liver disease (NAFLD) is defined by a set of hepatic conditions ranging
from steatosis to steatohepatitis (NASH), characterized by inflammation and fibrosis …

Advances in noninvasive biomarkers for nonalcoholic fatty liver disease

GE Gîlcă-Blanariu, DS Budur, DE Mitrică, E Gologan… - Metabolites, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) currently represents one of the most common liver
diseases worldwide. Early diagnosis and disease staging is crucial, since it is mainly …

Lipidomic Analysis Reveals Alterations in Hepatic FA Profile Associated With MASLD Stage in Patients With Obesity

MÁ Núñez-Sánchez… - The Journal of …, 2024 - academic.oup.com
Context Metabolic dysfunction–associated steatotic liver disease (MASLD) is characterized
by the intracellular lipid accumulation in hepatocytes. Excess caloric intake and high-fat …

Multidisciplinary lifestyle intervention is associated with improvements in liver damage and in surrogate scores of NAFLD and liver fibrosis in morbidly obese patients

M Bischoff, S Zimny, S Feiner, J Sauter, S Sydor… - European Journal of …, 2022 - Springer
Purpose Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the
metabolic syndrome. Particularly morbidly obese patients are at risk of developing …

(5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice

Y Dong, H Lu, Q Li, X Qi, Y Li, Z Zhang, J Chen, J Ren - Life sciences, 2019 - Elsevier
Abstract Aims (5R)-5-hydroxytriptolide (LLDT-8) is a triptolide analog with excellent
capability against cancers, cerebral ischemic injury and rheumatoid arthritis. Here, we …