Background Ineffective esophageal motility (IEM) is a heterogenous minor motility disorder
diagnosed when≥ 50% ineffective peristaltic sequences (distal contractile integral< 450 mm …

Abstract Background 22q11. 2 deletion syndrome (22q11DS), a copy number variation
(CNV) disorder, occurs in approximately 1: 4000 live births due to a heterozygous …

It is critical for the clinical success to take the anti-inflammatory function into consideration
when integrating the neurogenesis into the nerve repair materials. To this aim, we prepared …

Adeno-associated virus (AAV) capsid libraries have generated improved transgene delivery
vectors. We designed an AAV library construct, iTransduce, that combines a peptide library …

Although stem cell therapy holds enormous potential for treating debilitating injuries and
diseases in the central nervous system, low survival and inefficient differentiation have …

Adult neurogenesis is one of the most important mechanisms contributing to brain
development, learning, and memory. Alterations in neurogenesis underlie a wide spectrum …

Ruminococcus gnavus is a prevalent member of the human gut microbiota, which is over-
represented in inflammatory bowel disease and neurological disorders. We previously …

Neural stem cell (NSC) transplantation is an emerging strategy for restoring neuronal
function in neurological disorders, such as Parkinson's disease (PD), which is characterized …

The existence of neural stem cells (NSCs) in adult human brain neurogenic regions remains
unresolved. To address this, we created a cell atlas of the adult human subventricular zone …

Compromised structure and function of the blood-brain barrier (BBB) is one of the
pathological hallmarks of brain infection by HIV-1. BBB damage during HIV-1 infection has …