[HTML][HTML] Hydrogels for RNA delivery

R Zhong, S Talebian, BB Mendes, G Wallace… - Nature materials, 2023 - nature.com
RNA-based therapeutics have shown tremendous promise in disease intervention at the
genetic level, and some have been approved for clinical use, including the recent COVID-19 …

The current state and future directions of RNAi-based therapeutics

RL Setten, JJ Rossi, S Han - Nature reviews Drug discovery, 2019 - nature.com
The RNA interference (RNAi) pathway regulates mRNA stability and translation in nearly all
human cells. Small double-stranded RNA molecules can efficiently trigger RNAi silencing of …

[HTML][HTML] Nanotechnology-based delivery of CRISPR/Cas9 for cancer treatment

X Xu, C Liu, Y Wang, O Koivisto, J Zhou, Y Shu… - Advanced drug delivery …, 2021 - Elsevier
Abstract CRISPR/Cas9 (Clustered Regularly Interspaced Short Palindromic Repeats-
associated protein 9) is a potent technology for gene-editing. Owing to its high specificity …

Natural polymers-based light-induced hydrogels: Promising biomaterials for biomedical applications

H Samadian, H Maleki, Z Allahyari… - Coordination Chemistry …, 2020 - Elsevier
There has been a significant increase in demand for biomaterials over the last decades.
According to this fact, the design and development of more efficient and sophisticated …

Recent progress on polysaccharide-based hydrogels for controlled delivery of therapeutic biomolecules

MI Rial-Hermida, A Rey-Rico… - ACS Biomaterials …, 2021 - ACS Publications
A plethora of applications using polysaccharides have been developed in recent years due
to their availability as well as their frequent nontoxicity and biodegradability. These polymers …

Engineered hydrogels in cancer therapy and diagnosis

M Sepantafar, R Maheronnaghsh, H Mohammadi… - Trends in …, 2017 - cell.com
Over the last decade, numerous investigations have attempted to clarify the intricacies of
tumor development to propose effective approaches for cancer treatment. Thanks to the …

Multifunctional smart hydrogels: Potential in tissue engineering and cancer therapy

X Li, X Su - Journal of Materials Chemistry B, 2018 - pubs.rsc.org
In recent years, clinical applications have been proposed for various hydrogel products.
Hydrogels can be derived from animal tissues, plant extracts and/or adipose tissue …

Harnessing nucleic acids nanotechnology for bone/cartilage regeneration

Y Han, L Cao, G Li, F Zhou, L Bai, J Su - Small, 2023 - Wiley Online Library
The effective regeneration of weight‐bearing bone defects and critical‐sized cartilage
defects remains a significant clinical challenge. Traditional treatments such as autologous …

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

MK Nguyen, E Alsberg - Progress in polymer science, 2014 - Elsevier
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of
their ability to present sustained, localized and controlled release of bioactive factors …

[HTML][HTML] RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA

Q Leng, L Chen, Y Lv - Theranostics, 2020 - ncbi.nlm.nih.gov
Abstract Globally, more than 1.5 million patients undergo bone graft surgeries annually, and
the development of biomaterial scaffolds that mimic natural bone for bone grafting remains a …