The poor response of glioblastoma to current treatment protocols is a consequence of its
intrinsic drug resistance. Resistance to chemotherapy is primarily associated with …

Simple Summary The clinical success of cancer immunotherapy targeting immune
checkpoints (eg, PD-1, CTLA-4) has ushered in a new era of cancer therapeutics aimed at …

Drug resistance is one of the biggest challenges in the fight against cancer. In particular, in
the case of glioblastoma, the most lethal brain tumour, resistance to temozolomide (the …

Aim: This report proposes using the Hill model to assess the benchmark dose, the 50%
lethal dose, the cooperativity and the dissociation constant while analyzing cell viability data …

Background: Spheroids are in vitro quasi-spherical structures of cell aggregates, eventually
cultured within a hydrogel matrix, that are used, among other applications, as a …

The object of this study was the process of detecting anomalies in computer systems. The
task to timely detect anomalies in computer systems was solved, based on a mathematical …

The broad possibilities offered by microfluidic devices in relation to massive data monitoring
and acquisition open the door to the use of deep learning technologies in a very promising …

Glioblastoma (GBM) is a highly malignant brain tumour characterised by limited treatment
options and poor prognosis. The tumour microenvironment, particularly the central hypoxic …

The PD‐1 immune checkpoint‐based therapy has emerged as a promising therapy strategy
for treating the malignant brain tumor glioblastoma (GBM). However, patient response varies …

Background: Organoids are 3D in vitro models that fulfill a hierarchical function, representing
a small version of living tissues and, therefore, a good approximation of cellular …