Cyclin-dependent kinases (CDK) and their role in diseases development–review

P Łukasik, M Załuski, I Gutowska - International journal of molecular …, 2021 - mdpi.com
Cyclin-dependent kinases (CDKs) are involved in many crucial processes, such as cell cycle
and transcription, as well as communication, metabolism, and apoptosis. The kinases are …

The role of Cdk5 in neurological disorders

C Ao, C Li, J Chen, J Tan, L Zeng - Frontiers in cellular neuroscience, 2022 - frontiersin.org
Neurological disorders are a group of disorders with motor, sensory or cognitive damage,
caused by dysfunction of the central or peripheral nervous system. Cyclin-dependent …

CDK12: an emerging therapeutic target for cancer

GYL Lui, C Grandori, CJ Kemp - Journal of clinical pathology, 2018 - jcp.bmj.com
Cyclin-dependent kinase 12 (CDK12) belongs to the cyclin-dependent kinase (CDK) family
of serine/threonine protein kinases that regulate transcriptional and post-transcriptional …

CDK12: A Potent Target and Biomarker for Human Cancer Therapy

S Liang, L Hu, Z Wu, Z Chen, S Liu, X Xu, A Qian - Cells, 2020 - mdpi.com
Cyclin-dependent kinases (CDKs) are a group of serine/threonine protein kinases and play
crucial roles in various cellular processes by regulating cell cycle and gene transcription …

The emerging roles of CDK12 in tumorigenesis

H Paculová, J Kohoutek - Cell division, 2017 - Springer
Cyclin-dependent kinases (CDKs) are key regulators of both cell cycle progression and
transcription. Since dysregulation of CDKs is a frequently occurring event driving …

Current progress and novel strategies that target CDK12 for drug discovery

P Lei, J Zhang, P Liao, C Ren, J Wang… - European Journal of …, 2022 - Elsevier
CDK12 is a cyclin-dependent kinase that plays critical roles in DNA replication, transcription,
mRNA splicing, and DNA damage repair. CDK12 genomic changes, including mutation …

Oncogenic dysregulation of pre‐mRNA processing by protein kinases: challenges and therapeutic opportunities

C Naro, P Bielli, C Sette - The FEBS Journal, 2021 - Wiley Online Library
Alternative splicing and polyadenylation represent two major steps in pre‐mRNA‐
processing, which ensure proper gene expression and diversification of human …

Bovine embryo-secreted microRNA-30c is a potential non-invasive biomarker for hampered preimplantation developmental competence

X Lin, E Beckers, S Mc Cafferty, Y Gansemans… - Frontiers in …, 2019 - frontiersin.org
Recently, secreted microRNAs (miRNAs) have received a lot of attention since they may act
as autocrine factors. However, how secreted miRNAs influence embryonic development is …

Cdk12 maintains the integrity of adult axons by suppressing actin remodeling

LN Townsend, H Clarke, D Maddison, KM Jones… - Cell Death …, 2023 - nature.com
The role of cyclin-dependent kinases (CDKs) that are ubiquitously expressed in the adult
nervous system remains unclear. Cdk12 is enriched in terminally differentiated neurons …

Mouse model of congenital heart defects, dysmorphic facial features and intellectual developmental disorders as a result of non-functional CDK13

M Nováková, M Hampl, D Vrábel… - Frontiers in cell and …, 2019 - frontiersin.org
Congenital heart defects, dysmorphic facial features and intellectual developmental
disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 …