Molecular heterogeneity and immunosuppressive microenvironment in glioblastoma

S DeCordova, A Shastri, AG Tsolaki, H Yasmin… - Frontiers in …, 2020 - frontiersin.org
Glioblastoma (GBM) is the most aggressive primary brain tumor in adults, with a poor
prognosis, despite surgical resection combined with radio-and chemotherapy. The major …

Small interfering RNA (siRNA) to target genes and molecular pathways in glioblastoma therapy: Current status with an emphasis on delivery systems

S Mirzaei, MK Mahabady, A Zabolian, A Abbaspour… - Life Sciences, 2021 - Elsevier
Glioblastoma multiforme (GBM) is one of the worst brain tumors arising from glial cells,
causing many deaths annually. Surgery, chemotherapy, radiotherapy and immunotherapy …

Toll-like receptors and toll-like receptor-targeted immunotherapy against glioma

Y Xun, H Yang, B Kaminska, H You - Journal of hematology & oncology, 2021 - Springer
Glioma represents a fast proliferating and highly invasive brain tumor which is resistant to
current therapies and invariably recurs. Despite some advancements in anti-glioma …

Immunotherapy of glioblastoma: current strategies and challenges in tumor model development

B Majc, M Novak, N Kopitar-Jerala, A Jewett, B Breznik - Cells, 2021 - mdpi.com
Glioblastoma is the most common brain malignant tumor in the adult population, and
immunotherapy is playing an increasingly central role in the treatment of many cancers …

The role of cytokines and chemokines in shaping the immune microenvironment of glioblastoma: implications for immunotherapy

ECF Yeo, MP Brown, T Gargett, LM Ebert - Cells, 2021 - mdpi.com
Glioblastoma is the most common form of primary brain tumour in adults. For more than a
decade, conventional treatment has produced a relatively modest improvement in the …

Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses

SR Burks, CN Kersch, JA Witko… - Proceedings of the …, 2021 - National Acad Sciences
Intracarotid arterial hyperosmolar mannitol (ICAHM) blood–brain barrier disruption (BBBD)
is effective and safe for delivery of therapeutics for central nervous system malignancies …

Smart biomaterials to enhance the efficiency of immunotherapy in glioblastoma: State of the art and future perspectives

B Abadi, N Yazdanpanah, A Nokhodchi… - Advanced Drug Delivery …, 2021 - Elsevier
Glioblastoma multiform (GBM) is considered as the most lethal tumor among CNS
malignancies. Although immunotherapy has achieved remarkable advances in cancer …

Critical view of novel treatment strategies for glioblastoma: failure and success of resistance mechanisms by glioblastoma cells

T Burster, R Traut, Z Yermekkyzy, K Mayer… - Frontiers in Cell and …, 2021 - frontiersin.org
According to the invasive nature of glioblastoma, which is the most common form of
malignant brain tumor, the standard care by surgery, chemo-and radiotherapy is particularly …

[HTML][HTML] Recent treatment strategies and molecular pathways in resistance mechanisms of antiangiogenic therapies in glioblastoma

MA Rahman, MM Ali - Cancers, 2024 - mdpi.com
Simple Summary Glioblastoma (GBM) appears to be a challenging malignancy to
completely eradicate, with few significant improvements in treatment. This review explores …

Dendritic cell vaccines improve the glioma microenvironment: Influence, challenges, and future directions

J Zhou, L Li, M Jia, Q Liao, G Peng, G Luo… - Cancer …, 2023 - Wiley Online Library
Introduction Gliomas, especially the glioblastomas, are one of the most aggressive
intracranial tumors with poor prognosis. This might be explained by the heterogeneity of …