Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …

Purpose The discovery of specific and sensitive disease‐associated biomarkers for early
diagnostic purposes of many diseases is still highly challenging due to various complex …

Neutrophils constitute the largest proportion of nucleated peripheral blood cells, and
neutrophils have substantial heterogeneity. We profiled nearly 300,000 human peripheral …

Metabolic adaptations shape immune cell function. In the acute response, a metabolic
switch towards glycolysis is necessary for mounting a proinflammatory response. During the …

Background Spirometra mansoni can parasitize animals and humans through food and
water, causing parasitic zoonosis. Knowledge of the developmental process of S. mansoni is …

Sepsis, the dysregulated host response to infection causing life-threatening organ
dysfunction, is a global health challenge requiring better understanding of pathophysiology …

Human peripheral blood mononuclear cells (PBMCs) represent a sentinel blood sample
which reacts to different pathophysiological stimuli in the form of immunological responses …

Sepsis and sepsis-related diseases cause a high rate of mortality worldwide. The molecular
and cellular mechanisms of sepsis are still unclear. We aim to identify key genes in sepsis …

Sepsis is a major health issue and a leading cause of death in hospitals globally. The
treatment of sepsis is largely supportive, and there are no therapeutics available that target …

Sepsis is a life-threatening condition influenced by various factors. Although gene
expression profiling has offered new insights, accurately assessing patient risk and …